Abstract
Gout is the most common form of inflammatory arthritis in adults. Elevation serum uric acid (SUA) concentration is known to be the key to gout pathogenesis. Since the first genome-wide association study (GWAS) for SUA was performed in 2007, the number of gene loci known to be associated with hyperuricemia and gout has grown rapidly. GWASs and Mendelian randomization studies have also reported numerous novel results regarding the genetics of hyperuricemia and gout since 2018. We concisely review recent advances in scholarship on the effects of genetics on hyperuricemia and gout risk. We also review data from genetic association studies in Taiwan and perform GWASs of SUA levels among Taiwan Biobank participants.
| Original language | English |
|---|---|
| Pages (from-to) | 261-269 |
| Number of pages | 9 |
| Journal | Tzu Chi Medical Journal |
| Volume | 34 |
| Issue number | 3 |
| DOIs | |
| State | Published - 01 07 2022 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2022 Wolters Kluwer Medknow Publications. All rights reserved.
Keywords
- Genetics
- Genome-wide association study
- Gout
- Hyperuricemia
- Mendelian randomization study