Genetics of Severe Cutaneous Adverse Reactions

Shang Chen Yang; Chun Bing Chen; Mao Ying Lin; Zhi Yang Zhang; Xiao Yan Jia; Ming Huang; Ya Fen Zou; Wen Hung Chung

doi:10.3389/fmed.2021.652091

Genetics of Severe Cutaneous Adverse Reactions

Shang Chen Yang, Chun Bing Chen, Mao Ying Lin, Zhi Yang Zhang, Xiao Yan Jia, Ming Huang, Ya Fen Zou, Wen Hung Chung^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are T cells-mediated life-threatening immune reactions, most commonly induced by drug. The last decade has seen significant progress in SCARs research. Recent studies have unveiled the pathogenesis of SCARs involved in susceptible genes, including human leukocyte antigens (HLA) and drugs-T cell receptor (TCR) interaction that may trigger T cell activation with downstream immune signaling of cytokines/chemokines and specific cytotoxic proteins releases. Advances in identification of multiple genetic alleles associated with specific drugs related SCARS in different populations is an important breakthrough in recent years for prevention of SCARs. This article summarized the findings on genetic factors related to SJS/TEN, especially for HLA.

Original language	English
Article number	652091
Journal	Frontiers in Medicine
Volume	8
DOIs	https://doi.org/10.3389/fmed.2021.652091
State	Published - 15 07 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Yang, Chen, Lin, Zhang, Jia, Huang, Zou and Chung.

Keywords

Stevens–Johnson syndrome
genetic screen
pharmacogenomic
severe cutaneous adverse drug reactions
toxic epidermal necrolysis

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10.3389/fmed.2021.652091

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title = "Genetics of Severe Cutaneous Adverse Reactions",

abstract = "Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are T cells-mediated life-threatening immune reactions, most commonly induced by drug. The last decade has seen significant progress in SCARs research. Recent studies have unveiled the pathogenesis of SCARs involved in susceptible genes, including human leukocyte antigens (HLA) and drugs-T cell receptor (TCR) interaction that may trigger T cell activation with downstream immune signaling of cytokines/chemokines and specific cytotoxic proteins releases. Advances in identification of multiple genetic alleles associated with specific drugs related SCARS in different populations is an important breakthrough in recent years for prevention of SCARs. This article summarized the findings on genetic factors related to SJS/TEN, especially for HLA.",

keywords = "Stevens–Johnson syndrome, genetic screen, pharmacogenomic, severe cutaneous adverse drug reactions, toxic epidermal necrolysis",

author = "Yang, {Shang Chen} and Chen, {Chun Bing} and Lin, {Mao Ying} and Zhang, {Zhi Yang} and Jia, {Xiao Yan} and Ming Huang and Zou, {Ya Fen} and Chung, {Wen Hung}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Yang, Chen, Lin, Zhang, Jia, Huang, Zou and Chung.",

year = "2021",

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doi = "10.3389/fmed.2021.652091",

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T1 - Genetics of Severe Cutaneous Adverse Reactions

AU - Yang, Shang Chen

AU - Chen, Chun Bing

AU - Lin, Mao Ying

AU - Zhang, Zhi Yang

AU - Jia, Xiao Yan

AU - Huang, Ming

AU - Zou, Ya Fen

AU - Chung, Wen Hung

PY - 2021/7/15

Y1 - 2021/7/15

N2 - Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are T cells-mediated life-threatening immune reactions, most commonly induced by drug. The last decade has seen significant progress in SCARs research. Recent studies have unveiled the pathogenesis of SCARs involved in susceptible genes, including human leukocyte antigens (HLA) and drugs-T cell receptor (TCR) interaction that may trigger T cell activation with downstream immune signaling of cytokines/chemokines and specific cytotoxic proteins releases. Advances in identification of multiple genetic alleles associated with specific drugs related SCARS in different populations is an important breakthrough in recent years for prevention of SCARs. This article summarized the findings on genetic factors related to SJS/TEN, especially for HLA.

AB - Severe cutaneous adverse reactions (SCARs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS) are T cells-mediated life-threatening immune reactions, most commonly induced by drug. The last decade has seen significant progress in SCARs research. Recent studies have unveiled the pathogenesis of SCARs involved in susceptible genes, including human leukocyte antigens (HLA) and drugs-T cell receptor (TCR) interaction that may trigger T cell activation with downstream immune signaling of cytokines/chemokines and specific cytotoxic proteins releases. Advances in identification of multiple genetic alleles associated with specific drugs related SCARS in different populations is an important breakthrough in recent years for prevention of SCARs. This article summarized the findings on genetic factors related to SJS/TEN, especially for HLA.

KW - Stevens–Johnson syndrome

KW - genetic screen

KW - pharmacogenomic

KW - severe cutaneous adverse drug reactions

KW - toxic epidermal necrolysis

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DO - 10.3389/fmed.2021.652091

M3 - 文献综述

AN - SCOPUS:85111559306

VL - 8

JO - Frontiers in Medicine

JF - Frontiers in Medicine

M1 - 652091

ER -

Genetics of Severe Cutaneous Adverse Reactions

Abstract

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Keywords

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