Genome-wide association study of bipolar i disorder in the Han Chinese population

M. T.M. Lee; C. H. Chen; C. S. Lee; C. C. Chen; M. Y. Chong; W. C. Ouyang; N. Y. Chiu; L. J. Chuo; C. Y. Chen; H. K.L. Tan; H. Y. Lane; T. J. Chang; C. H. Lin; S. H. Jou; Y. M. Hou; J. Feng; T. J. Lai; C. L. Tung; T. J. Chen; C. J. Chang; F. W. Lung; C. K. Chen; I. S. Shiah; C. Y. Liu; P. R. Teng; K. H. Chen; L. J. Shen; C. S. Cheng; T. P. Chang; C. F. Li; C. H. Chou; C. Y. Chen; K. H.T. Wang; C. S.J. Fann; J. Y. Wu; Y. T. Chen; A. T.A. Cheng

doi:10.1038/mp.2010.43

Genome-wide association study of bipolar i disorder in the Han Chinese population

M. T.M. Lee, C. H. Chen, C. S. Lee, C. C. Chen, M. Y. Chong, W. C. Ouyang, N. Y. Chiu, L. J. Chuo, C. Y. Chen, H. K.L. Tan, H. Y. Lane, T. J. Chang, C. H. Lin, S. H. Jou, Y. M. Hou, J. Feng, T. J. Lai, C. L. Tung, T. J. Chen, C. J. ChangF. W. Lung, C. K. Chen, I. S. Shiah, C. Y. Liu, P. R. Teng, K. H. Chen, L. J. Shen, C. S. Cheng, T. P. Chang, C. F. Li, C. H. Chou, C. Y. Chen, K. H.T. Wang, C. S.J. Fann, J. Y. Wu, Y. T. Chen, A. T.A. Cheng

School of Medicine

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Abstract

We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10^-7 (rs2709736) and 6.05 × 10^-6 (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P9.74 × 10^-6) and in CACNB2 (Calcium channel, voltage-dependent, Β-2 subunit) gene (rs11013860, P=5.15 × 10 ^-5), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10^-5 and P=1.48 × 10^-5, respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.

Original language	English
Pages (from-to)	548-556
Number of pages	9
Journal	Molecular Psychiatry
Volume	16
Issue number	5
DOIs	https://doi.org/10.1038/mp.2010.43
State	Published - 05 2011

Keywords

ANK3
CACNB2
KCTD12
SP8
ST8SIA2
bipolar genome study

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10.1038/mp.2010.43

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Lee, M. T. M., Chen, C. H., Lee, C. S., Chen, C. C., Chong, M. Y., Ouyang, W. C., Chiu, N. Y., Chuo, L. J., Chen, C. Y., Tan, H. K. L., Lane, H. Y., Chang, T. J., Lin, C. H., Jou, S. H., Hou, Y. M., Feng, J., Lai, T. J., Tung, C. L., Chen, T. J., ... Cheng, A. T. A. (2011). Genome-wide association study of bipolar i disorder in the Han Chinese population. Molecular Psychiatry, 16(5), 548-556. https://doi.org/10.1038/mp.2010.43

@article{b573f7d9fc6041f99c42912023a75e21,

title = "Genome-wide association study of bipolar i disorder in the Han Chinese population",

abstract = "We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10-7 (rs2709736) and 6.05 × 10-6 (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P9.74 × 10-6) and in CACNB2 (Calcium channel, voltage-dependent, Β-2 subunit) gene (rs11013860, P=5.15 × 10 -5), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10-5 and P=1.48 × 10-5, respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.",

keywords = "ANK3, CACNB2, KCTD12, SP8, ST8SIA2, bipolar genome study",

author = "Lee, {M. T.M.} and Chen, {C. H.} and Lee, {C. S.} and Chen, {C. C.} and Chong, {M. Y.} and Ouyang, {W. C.} and Chiu, {N. Y.} and Chuo, {L. J.} and Chen, {C. Y.} and Tan, {H. K.L.} and Lane, {H. Y.} and Chang, {T. J.} and Lin, {C. H.} and Jou, {S. H.} and Hou, {Y. M.} and J. Feng and Lai, {T. J.} and Tung, {C. L.} and Chen, {T. J.} and Chang, {C. J.} and Lung, {F. W.} and Chen, {C. K.} and Shiah, {I. S.} and Liu, {C. Y.} and Teng, {P. R.} and Chen, {K. H.} and Shen, {L. J.} and Cheng, {C. S.} and Chang, {T. P.} and Li, {C. F.} and Chou, {C. H.} and Chen, {C. Y.} and Wang, {K. H.T.} and Fann, {C. S.J.} and Wu, {J. Y.} and Chen, {Y. T.} and Cheng, {A. T.A.}",

year = "2011",

month = may,

doi = "10.1038/mp.2010.43",

language = "英语",

volume = "16",

pages = "548--556",

journal = "Molecular Psychiatry",

issn = "1359-4184",

publisher = "Springer Nature",

number = "5",

}

Lee, MTM, Chen, CH, Lee, CS, Chen, CC, Chong, MY, Ouyang, WC, Chiu, NY, Chuo, LJ, Chen, CY, Tan, HKL, Lane, HY, Chang, TJ, Lin, CH, Jou, SH, Hou, YM, Feng, J, Lai, TJ, Tung, CL, Chen, TJ, Chang, CJ, Lung, FW, Chen, CK, Shiah, IS, Liu, CY, Teng, PR, Chen, KH, Shen, LJ, Cheng, CS, Chang, TP, Li, CF, Chou, CH, Chen, CY, Wang, KHT, Fann, CSJ, Wu, JY, Chen, YT & Cheng, ATA 2011, 'Genome-wide association study of bipolar i disorder in the Han Chinese population', Molecular Psychiatry, vol. 16, no. 5, pp. 548-556. https://doi.org/10.1038/mp.2010.43

TY - JOUR

T1 - Genome-wide association study of bipolar i disorder in the Han Chinese population

AU - Lee, M. T.M.

AU - Chen, C. H.

AU - Lee, C. S.

AU - Chen, C. C.

AU - Chong, M. Y.

AU - Ouyang, W. C.

AU - Chiu, N. Y.

AU - Chuo, L. J.

AU - Chen, C. Y.

AU - Tan, H. K.L.

AU - Lane, H. Y.

AU - Chang, T. J.

AU - Lin, C. H.

AU - Jou, S. H.

AU - Hou, Y. M.

AU - Feng, J.

AU - Lai, T. J.

AU - Tung, C. L.

AU - Chen, T. J.

AU - Chang, C. J.

AU - Lung, F. W.

AU - Chen, C. K.

AU - Shiah, I. S.

AU - Liu, C. Y.

AU - Teng, P. R.

AU - Chen, K. H.

AU - Shen, L. J.

AU - Cheng, C. S.

AU - Chang, T. P.

AU - Li, C. F.

AU - Chou, C. H.

AU - Chen, C. Y.

AU - Wang, K. H.T.

AU - Fann, C. S.J.

AU - Wu, J. Y.

AU - Chen, Y. T.

AU - Cheng, A. T.A.

PY - 2011/5

Y1 - 2011/5

N2 - We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10-7 (rs2709736) and 6.05 × 10-6 (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P9.74 × 10-6) and in CACNB2 (Calcium channel, voltage-dependent, Β-2 subunit) gene (rs11013860, P=5.15 × 10 -5), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10-5 and P=1.48 × 10-5, respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.

AB - We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10-7 (rs2709736) and 6.05 × 10-6 (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P9.74 × 10-6) and in CACNB2 (Calcium channel, voltage-dependent, Β-2 subunit) gene (rs11013860, P=5.15 × 10 -5), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10-5 and P=1.48 × 10-5, respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.

KW - ANK3

KW - CACNB2

KW - KCTD12

KW - SP8

KW - ST8SIA2

KW - bipolar genome study

UR - http://www.scopus.com/inward/record.url?scp=79955473843&partnerID=8YFLogxK

U2 - 10.1038/mp.2010.43

DO - 10.1038/mp.2010.43

M3 - 文章

C2 - 20386566

AN - SCOPUS:79955473843

SN - 1359-4184

VL - 16

SP - 548

EP - 556

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 5

ER -

Genome-wide association study of bipolar i disorder in the Han Chinese population

Abstract

Keywords

UN SDGs

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