Genomic structure of carp mitogen-activated protein kinase kinase gene

Jiann Horng Leu; Ming Shyue Lee; Kuan Tien Chen; Geen Dong Chang; Chen Kung Chou; Chang Jen Huang

doi:10.1016/0167-4781(96)00023-1

Genomic structure of carp mitogen-activated protein kinase kinase gene

Jiann Horng Leu, Ming Shyue Lee, Kuan Tien Chen, Geen Dong Chang, Chen Kung Chou, Chang Jen Huang^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

Carp mitogen-activated protein kinase kinase 1 (cMKKI) gene was isolated from a liver genomic library. The sequence around the exon-intron boundaries and 2 kb of the promoter region were determined. Our data indicate that this gene is composed of 11 exons and 10 introns spanning about 9 kb. Multiple potential transcription initiation sites were located by primer extension analysis. Examination of 2 kb of 5′-flanking sequence revealed potential binding sites for a variety of transcription factors such as E2F, Ets-1, GATA-1, Myb, NF-IL6, Sp1, and NF-kB.

Original language	English
Pages (from-to)	133-136
Number of pages	4
Journal	BBA - Gene Structure and Expression
Volume	1306
Issue number	2-3
DOIs	https://doi.org/10.1016/0167-4781(96)00023-1
State	Published - 02 05 1996
Externally published	Yes

Keywords

(Cyprinus carpio)
Genomic DNA sequence
Mitogen-activated protein kinase kinase

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10.1016/0167-4781(96)00023-1

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title = "Genomic structure of carp mitogen-activated protein kinase kinase gene",

abstract = "Carp mitogen-activated protein kinase kinase 1 (cMKKI) gene was isolated from a liver genomic library. The sequence around the exon-intron boundaries and 2 kb of the promoter region were determined. Our data indicate that this gene is composed of 11 exons and 10 introns spanning about 9 kb. Multiple potential transcription initiation sites were located by primer extension analysis. Examination of 2 kb of 5′-flanking sequence revealed potential binding sites for a variety of transcription factors such as E2F, Ets-1, GATA-1, Myb, NF-IL6, Sp1, and NF-kB.",

keywords = "(Cyprinus carpio), Genomic DNA sequence, Mitogen-activated protein kinase kinase",

author = "Leu, {Jiann Horng} and Lee, {Ming Shyue} and Chen, {Kuan Tien} and Chang, {Geen Dong} and Chou, {Chen Kung} and Huang, {Chang Jen}",

year = "1996",

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doi = "10.1016/0167-4781(96)00023-1",

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T1 - Genomic structure of carp mitogen-activated protein kinase kinase gene

AU - Leu, Jiann Horng

AU - Lee, Ming Shyue

AU - Chen, Kuan Tien

AU - Chang, Geen Dong

AU - Chou, Chen Kung

AU - Huang, Chang Jen

PY - 1996/5/2

Y1 - 1996/5/2

N2 - Carp mitogen-activated protein kinase kinase 1 (cMKKI) gene was isolated from a liver genomic library. The sequence around the exon-intron boundaries and 2 kb of the promoter region were determined. Our data indicate that this gene is composed of 11 exons and 10 introns spanning about 9 kb. Multiple potential transcription initiation sites were located by primer extension analysis. Examination of 2 kb of 5′-flanking sequence revealed potential binding sites for a variety of transcription factors such as E2F, Ets-1, GATA-1, Myb, NF-IL6, Sp1, and NF-kB.

AB - Carp mitogen-activated protein kinase kinase 1 (cMKKI) gene was isolated from a liver genomic library. The sequence around the exon-intron boundaries and 2 kb of the promoter region were determined. Our data indicate that this gene is composed of 11 exons and 10 introns spanning about 9 kb. Multiple potential transcription initiation sites were located by primer extension analysis. Examination of 2 kb of 5′-flanking sequence revealed potential binding sites for a variety of transcription factors such as E2F, Ets-1, GATA-1, Myb, NF-IL6, Sp1, and NF-kB.

KW - (Cyprinus carpio)

KW - Genomic DNA sequence

KW - Mitogen-activated protein kinase kinase

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DO - 10.1016/0167-4781(96)00023-1

M3 - 文章

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AN - SCOPUS:0029993059

SN - 0167-4781

VL - 1306

SP - 133

EP - 136

JO - BBA - Gene Structure and Expression

JF - BBA - Gene Structure and Expression

IS - 2-3

ER -

Genomic structure of carp mitogen-activated protein kinase kinase gene

Abstract

Keywords

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