Genomic structure of carp mitogen-activated protein kinase kinase gene

Jiann Horng Leu, Ming Shyue Lee, Kuan Tien Chen, Geen Dong Chang, Chen Kung Chou, Chang Jen Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations


Carp mitogen-activated protein kinase kinase 1 (cMKKI) gene was isolated from a liver genomic library. The sequence around the exon-intron boundaries and 2 kb of the promoter region were determined. Our data indicate that this gene is composed of 11 exons and 10 introns spanning about 9 kb. Multiple potential transcription initiation sites were located by primer extension analysis. Examination of 2 kb of 5′-flanking sequence revealed potential binding sites for a variety of transcription factors such as E2F, Ets-1, GATA-1, Myb, NF-IL6, Sp1, and NF-kB.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalBBA - Gene Structure and Expression
Issue number2-3
StatePublished - 02 05 1996
Externally publishedYes


  • (Cyprinus carpio)
  • Genomic DNA sequence
  • Mitogen-activated protein kinase kinase


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