Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

Pei Hung Chang; Cheng Hsu Wang; Eric Yen Chao Chen; Shih Wei Yang; Wen Chi Chou; Jason Chia Hsun Hsieh; Feng Che Kuan; Kun Yun Yeh

doi:10.21147/j.issn.1000-9604.2017.03.02

Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

Pei Hung Chang, Cheng Hsu Wang, Eric Yen Chao Chen, Shih Wei Yang, Wen Chi Chou, Jason Chia Hsun Hsieh, Feng Che Kuan, Kun Yun Yeh^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

9 Scopus citations

Abstract

Objective: This study aims to evaluate the impact and potential prognostic roles of the pre-and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). Methods: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre-and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival. Results: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage. Conclusions: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.

Original language	English
Pages (from-to)	172-178
Number of pages	7
Journal	Chinese Journal of Cancer Research
Volume	29
Issue number	3
DOIs	https://doi.org/10.21147/j.issn.1000-9604.2017.03.02
State	Published - 06 2017

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Publisher Copyright:
© Chinese Journal of Cancer Research. All rights reserved.

Keywords

Cachexia
Chemoradiation
Glasgow prognostic score (GPS)
Head and neck cancer
Inflammation
Nutrition

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10.21147/j.issn.1000-9604.2017.03.02

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title = "Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer",

abstract = "Objective: This study aims to evaluate the impact and potential prognostic roles of the pre-and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). Methods: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre-and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival. Results: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage. Conclusions: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.",

keywords = "Cachexia, Chemoradiation, Glasgow prognostic score (GPS), Head and neck cancer, Inflammation, Nutrition",

author = "Chang, {Pei Hung} and Wang, {Cheng Hsu} and Chen, {Eric Yen Chao} and Yang, {Shih Wei} and Chou, {Wen Chi} and Hsieh, {Jason Chia Hsun} and Kuan, {Feng Che} and Yeh, {Kun Yun}",

year = "2017",

month = jun,

doi = "10.21147/j.issn.1000-9604.2017.03.02",

language = "英语",

volume = "29",

pages = "172--178",

journal = "Chinese Journal of Cancer Research",

issn = "1000-9604",

publisher = "Beijing Institute for Cancer Research",

number = "3",

}

TY - JOUR

T1 - Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

AU - Chang, Pei Hung

AU - Wang, Cheng Hsu

AU - Chen, Eric Yen Chao

AU - Yang, Shih Wei

AU - Chou, Wen Chi

AU - Hsieh, Jason Chia Hsun

AU - Kuan, Feng Che

AU - Yeh, Kun Yun

PY - 2017/6

Y1 - 2017/6

N2 - Objective: This study aims to evaluate the impact and potential prognostic roles of the pre-and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). Methods: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre-and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival. Results: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage. Conclusions: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.

AB - Objective: This study aims to evaluate the impact and potential prognostic roles of the pre-and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). Methods: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre-and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival. Results: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage. Conclusions: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.

KW - Cachexia

KW - Chemoradiation

KW - Glasgow prognostic score (GPS)

KW - Head and neck cancer

KW - Inflammation

KW - Nutrition

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U2 - 10.21147/j.issn.1000-9604.2017.03.02

DO - 10.21147/j.issn.1000-9604.2017.03.02

M3 - 文章

AN - SCOPUS:85026294445

SN - 1000-9604

VL - 29

SP - 172

EP - 178

JO - Chinese Journal of Cancer Research

JF - Chinese Journal of Cancer Research

IS - 3

ER -

Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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