Glucose-6-phosphate dehydrogenase-beyond the realm of red cell biology

H. Y. Ho*, M. L. Cheng, D. T.Y. Chiu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

35 Scopus citations

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) is critical to the maintenance of NADPH pool and redox homeostasis. Conventionally, G6PD deficiency has been associated with hemolytic disorders. Most biochemical variants were identified and characterized at molecular level. Recently, a number of studies have shone light on the roles of G6PD in aspects of physiology other than erythrocytic pathophysiology. G6PD deficiency alters the redox homeostasis, and affects dysfunctional cell growth and signaling, anomalous embryonic development, and altered susceptibility to infection. The present article gives a brief review of basic science and clinical findings about G6PD, and covers the latest development in the field. Moreover, how G6PD status alters the susceptibility of the affected individuals to certain degenerative diseases is also discussed.

Original languageEnglish
Pages (from-to)1028-1048
Number of pages21
JournalFree Radical Research
Volume48
Issue number9
DOIs
StatePublished - 09 2014

Keywords

  • Antioxidant
  • G6PD
  • NADPH
  • Reactive oxygen species

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