Glucose detection in a highly scattering medium with diffuse photon-pair density wave

Li Ping Yu, Jheng Syong Wu, Sheng Yi Chang, Chien Chou*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations


We propose a novel optical method for glucose measurement based on diffuse photon-pair density wave (DPPDW) in a multiple scattering medium (MSM) where the light scattering of photon-pair is induced by refractive index mismatch between scatters and phantom solution. Experimentally, the DPPDW propagates in MSM via a two-frequency laser (TFL) beam wherein highly correlated pairs of linear polarized photons are generated. The reduced scattering coefficient μ2s′ and absorption coefficient μ2a of DPPDW are measured simultaneously in terms of the amplitude and phase measurements of the detected heterodyne signal under arrangement at different distances between the source and detection fibers in MSM. The results show that the sensitivity of glucose detection via glucose-induced change of reduced scattering coefficient (μ2s′) is 0.049%mM-1 in a 1% intralipid solution. In addition, the linear range of μ2s′ vs glucose concentration implies that this DPPDW method can be used to monitor glucose concentration continuously and noninvasively subcutaneously.

Original languageEnglish
Article number1650032
JournalJournal of Innovative Optical Health Sciences
Issue number1
StatePublished - 01 01 2017

Bibliographical note

Publisher Copyright:
© 2017 The Author(s).


  • Diffuse photon-pair density wave
  • glucose
  • multiple scattering
  • polarization gating
  • spatial coherence gating


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