Glutathione and Caffeine Antagonize the Sperm-Immobilizing Effect of a Vaginal Contraceptive

C. Y. Hong; B. N. Chiang; J. ku; Y. H. Wei

doi:10.1177/096032718400300403

Glutathione and Caffeine Antagonize the Sperm-Immobilizing Effect of a Vaginal Contraceptive

C. Y. Hong, B. N. Chiang, J. ku, Y. H. Wei

Veterans General Hospital-Taipei

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

1 The concentration-dependent inhibition of Neosampoon, a vaginal contraceptive, on ejaculated human sperm motility was studied with a transmembrane migration method. 2 Caffeine (5mM), glutathione (5mM) and glutathione (15mM) all reactivated the motility of Neosampoon-immobilized sperm. 3 Caffeine (5mM) was more potent than glutathione in antagonizing Neosampoon; there was no difference between the potency of 5mM- and 15mM-glutathione. 4 Human sperm motility could be a model for studying the interaction of membrane-active drugs, including the protective effect of glutathione against membrane-disrupting agents.

Original language	English
Pages (from-to)	271-277
Number of pages	7
Journal	Human and Experimental Toxicology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1177/096032718400300403
State	Published - 07 1984
Externally published	Yes

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title = "Glutathione and Caffeine Antagonize the Sperm-Immobilizing Effect of a Vaginal Contraceptive",

abstract = "1 The concentration-dependent inhibition of Neosampoon, a vaginal contraceptive, on ejaculated human sperm motility was studied with a transmembrane migration method. 2 Caffeine (5mM), glutathione (5mM) and glutathione (15mM) all reactivated the motility of Neosampoon-immobilized sperm. 3 Caffeine (5mM) was more potent than glutathione in antagonizing Neosampoon; there was no difference between the potency of 5mM- and 15mM-glutathione. 4 Human sperm motility could be a model for studying the interaction of membrane-active drugs, including the protective effect of glutathione against membrane-disrupting agents.",

author = "Hong, {C. Y.} and Chiang, {B. N.} and J. ku and Wei, {Y. H.}",

year = "1984",

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AU - ku, J.

AU - Wei, Y. H.

PY - 1984/7

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AB - 1 The concentration-dependent inhibition of Neosampoon, a vaginal contraceptive, on ejaculated human sperm motility was studied with a transmembrane migration method. 2 Caffeine (5mM), glutathione (5mM) and glutathione (15mM) all reactivated the motility of Neosampoon-immobilized sperm. 3 Caffeine (5mM) was more potent than glutathione in antagonizing Neosampoon; there was no difference between the potency of 5mM- and 15mM-glutathione. 4 Human sperm motility could be a model for studying the interaction of membrane-active drugs, including the protective effect of glutathione against membrane-disrupting agents.

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ER -

Glutathione and Caffeine Antagonize the Sperm-Immobilizing Effect of a Vaginal Contraceptive

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