Glutathione and Caffeine Antagonize the Sperm-Immobilizing Effect of a Vaginal Contraceptive

C. Y. Hong, B. N. Chiang, J. ku, Y. H. Wei

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations

Abstract

1 The concentration-dependent inhibition of Neosampoon, a vaginal contraceptive, on ejaculated human sperm motility was studied with a transmembrane migration method. 2 Caffeine (5mM), glutathione (5mM) and glutathione (15mM) all reactivated the motility of Neosampoon-immobilized sperm. 3 Caffeine (5mM) was more potent than glutathione in antagonizing Neosampoon; there was no difference between the potency of 5mM- and 15mM-glutathione. 4 Human sperm motility could be a model for studying the interaction of membrane-active drugs, including the protective effect of glutathione against membrane-disrupting agents.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalHuman and Experimental Toxicology
Volume3
Issue number4
DOIs
StatePublished - 07 1984
Externally publishedYes

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