Glycemic control and adherence to basal insulin therapy in Taiwanese patients with type 2 diabetes mellitus

Ming Nan Chien, Yen Ling Chen, Yi Jen Hung, Shu Yi Wang, Wen Tsung Lu, Chih Hung Chen, Ching Ling Lin, Tze Pao Huang, Ming Han Tsai, Wei Kung Tseng, Ta Jen Wu, Cheng Ho, Wen Yu Lin, Bill Chen, Lee Ming Chuang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations


Aims/Introduction: The aim of the present study was to assess the glycemic control, adherence and treatment satisfaction in a real-world setting with basal insulin therapy in type 2 diabetes patients in Taiwan. Materials and Methods: This was a multicenter, prospective, observational registry. A total of 836 patients with type 2 diabetes taking oral antidiabetic drugs with glycated hemoglobin (HbA1c) >7% entered the study. Basal insulin was given for 24 weeks. All treatment choices and medical instructions were at the physician's discretion to reflect real-life practice. Results: After 24-week treatment, 11.7% of patients reached set HbA1c goals without severe hypoglycemia (primary effectiveness end-point). HbA1c and fasting blood glucose were significantly decreased from (mean ± SD) 10.1 ± 1.9% to 8.7 ± 1.7% (−1.4 ± 2.1%, P < 0.0001) and from 230.6 ± 68.8 mg/dL to 159.1 ± 55.6 mg/dL (−67.4 ± 72.3 mg/dL, P < 0.0001), respectively. Patients received insulin therapy at a frequency of nearly one shot per day on average, whereas self-monitoring of blood glucose was carried out approximately four times a week. Hypoglycemia was reported by 11.4% of patients, and only 0.7% of patients experienced severe hypoglycemia. Slight changes in weight (0.7 ± 2.4 kg) and a low incidence of adverse drug reactions (0.4%) were also noted. The score of 7-point treatment satisfaction rated by patients was significantly improved by 1.9 ± 1.7 (P < 0.0001). Conclusions: Basal insulin therapy was associated with a decrease in HbA1c and fasting blood glucose, and an improved treatment satisfaction. Most patients complied with physicians' instructions. The treatment was generally well tolerated by patients with type 2 diabetes, but findings pointed out the need to reinforce the early and appropriate uptitration to achieve treatment targets.

Original languageEnglish
Pages (from-to)881-888
Number of pages8
JournalJournal of Diabetes Investigation
Issue number6
StatePublished - 01 11 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd


  • Insulin therapy
  • Observational study
  • Type 2 diabetes mellitus


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