Glycine enhancement of caudate neuronal activities: Relationship with the dopaminergic nigrostriatal pathway

Edward P. Finnerty*, Samuel H.H. Chan

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations

Abstract

Glycine microinjection into the substantia nigra zona compacta (SNC) in lightly anesthetized rats produced a marked and rapid decrease in spontaneous discharges of SNC neurons and a simultaneous enhancement of caudate nucleus (CN) activities. In animals pretreated with the dopamine receptor blocker, haloperidol, intranigral microinjection of glycine produced a dissociation of the nigral inhibition and caudate excitation. The SNC neurons were similarly suppresed with the CN neurons exhibited no discernible changes in firing frequency. A possible role was suggedted fro glycine as an inhibitory neurotransmitter acting on the cells of origin of the nigrostriatal pathway.

Original languageEnglish
Pages (from-to)477-479
Number of pages3
JournalEuropean Journal of Pharmacology
Volume67
Issue number4
DOIs
StatePublished - 1980
Externally publishedYes

Keywords

  • Caudate nucleus
  • Dopamine
  • Glycine
  • Haloperidol
  • Substantia nigra

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