GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging Β-amyloid plaques in human brain

Cheng Hsiang Yao; Kun Ju Lin; Chi Chang Weng; Ing Tsung Hsiao; Yi Shu Ting; Tzu Chen Yen; Tong Rong Jan; Daniel Skovronsky; Mei Ping Kung; Shiaw Pyng Wey

doi:10.1016/j.apradiso.2010.07.001

GMP-compliant automated synthesis of [¹⁸F]AV-45 (Florbetapir F 18) for imaging Β-amyloid plaques in human brain

Cheng Hsiang Yao, Kun Ju Lin, Chi Chang Weng, Ing Tsung Hsiao, Yi Shu Ting, Tzu Chen Yen, Tong Rong Jan, Daniel Skovronsky, Mei Ping Kung, Shiaw Pyng Wey^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

56 Scopus citations

Abstract

We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of ¹⁸F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of Β-amyloid (AΒ) plaques in the brain of Alzheimer's disease patients. [¹⁸F]AV-45 was prepared in 105min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4±7.7% with a final radiochemical purity of 95.3±2.2% (n=19). The specific activity of [¹⁸F]AV-45 reached as high as 470±135TBq/mmol (n=19). The present studies show that [¹⁸F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.

Original language	English
Pages (from-to)	2293-2297
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	68
Issue number	12
DOIs	https://doi.org/10.1016/j.apradiso.2010.07.001
State	Published - 12 2010

Keywords

Alzheimer's disease
PET tracer synthesis
Β-amyloid plaque imaging

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10.1016/j.apradiso.2010.07.001

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title = "GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging Β-amyloid plaques in human brain",

abstract = "We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of 18F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of Β-amyloid (AΒ) plaques in the brain of Alzheimer's disease patients. [18F]AV-45 was prepared in 105min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4±7.7% with a final radiochemical purity of 95.3±2.2% (n=19). The specific activity of [18F]AV-45 reached as high as 470±135TBq/mmol (n=19). The present studies show that [18F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.",

keywords = "Alzheimer's disease, PET tracer synthesis, Β-amyloid plaque imaging",

author = "Yao, {Cheng Hsiang} and Lin, {Kun Ju} and Weng, {Chi Chang} and Hsiao, {Ing Tsung} and Ting, {Yi Shu} and Yen, {Tzu Chen} and Jan, {Tong Rong} and Daniel Skovronsky and Kung, {Mei Ping} and Wey, {Shiaw Pyng}",

year = "2010",

month = dec,

doi = "10.1016/j.apradiso.2010.07.001",

language = "英语",

volume = "68",

pages = "2293--2297",

journal = "Applied Radiation and Isotopes",

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publisher = "Elsevier Ltd",

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T1 - GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging Β-amyloid plaques in human brain

AU - Yao, Cheng Hsiang

AU - Lin, Kun Ju

AU - Weng, Chi Chang

AU - Hsiao, Ing Tsung

AU - Ting, Yi Shu

AU - Yen, Tzu Chen

AU - Jan, Tong Rong

AU - Skovronsky, Daniel

AU - Kung, Mei Ping

AU - Wey, Shiaw Pyng

PY - 2010/12

Y1 - 2010/12

N2 - We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of 18F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of Β-amyloid (AΒ) plaques in the brain of Alzheimer's disease patients. [18F]AV-45 was prepared in 105min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4±7.7% with a final radiochemical purity of 95.3±2.2% (n=19). The specific activity of [18F]AV-45 reached as high as 470±135TBq/mmol (n=19). The present studies show that [18F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.

AB - We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of 18F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of Β-amyloid (AΒ) plaques in the brain of Alzheimer's disease patients. [18F]AV-45 was prepared in 105min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4±7.7% with a final radiochemical purity of 95.3±2.2% (n=19). The specific activity of [18F]AV-45 reached as high as 470±135TBq/mmol (n=19). The present studies show that [18F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.

KW - Alzheimer's disease

KW - PET tracer synthesis

KW - Β-amyloid plaque imaging

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U2 - 10.1016/j.apradiso.2010.07.001

DO - 10.1016/j.apradiso.2010.07.001

M3 - 文章

C2 - 20638295

AN - SCOPUS:77956412778

SN - 0969-8043

VL - 68

SP - 2293

EP - 2297

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 12

ER -

GMP-compliant automated synthesis of [¹⁸F]AV-45 (Florbetapir F 18) for imaging Β-amyloid plaques in human brain

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Keywords

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