GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging Β-amyloid plaques in human brain

Cheng Hsiang Yao; Kun Ju Lin; Chi Chang Weng; Ing Tsung Hsiao; Yi Shu Ting; Tzu Chen Yen; Tong Rong Jan; Daniel Skovronsky; Mei Ping Kung; Shiaw Pyng Wey

doi:10.1016/j.apradiso.2010.07.001

GMP-compliant automated synthesis of [¹⁸F]AV-45 (Florbetapir F 18) for imaging Β-amyloid plaques in human brain

Cheng Hsiang Yao
, Kun Ju Lin
, Chi Chang Weng
, Ing Tsung Hsiao
, Yi Shu Ting
, Tzu Chen Yen
, Tong Rong Jan
, Daniel Skovronsky
, Mei Ping Kung
, Shiaw Pyng Wey^*

^*Corresponding author for this work

Chang Gung Memorial Hospital
National Taiwan University
Eli Lilly
University of Pennsylvania

Research output: Contribution to journal › Journal Article › peer-review

58 Scopus citations

Abstract

We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of ¹⁸F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of Β-amyloid (AΒ) plaques in the brain of Alzheimer's disease patients. [¹⁸F]AV-45 was prepared in 105min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4±7.7% with a final radiochemical purity of 95.3±2.2% (n=19). The specific activity of [¹⁸F]AV-45 reached as high as 470±135TBq/mmol (n=19). The present studies show that [¹⁸F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.

Original language	English
Pages (from-to)	2293-2297
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	68
Issue number	12
DOIs	https://doi.org/10.1016/j.apradiso.2010.07.001
State	Published - 12 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Keywords

Alzheimer's disease
PET tracer synthesis
Β-amyloid plaque imaging

Access to Document

10.1016/j.apradiso.2010.07.001

Cite this

@article{43cc31b960c0488fa4bb7345023350d6,

title = "GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging Β-amyloid plaques in human brain",

abstract = "We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of 18F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of Β-amyloid (AΒ) plaques in the brain of Alzheimer's disease patients. [18F]AV-45 was prepared in 105min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4±7.7\% with a final radiochemical purity of 95.3±2.2\% (n=19). The specific activity of [18F]AV-45 reached as high as 470±135TBq/mmol (n=19). The present studies show that [18F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.",

keywords = "Alzheimer's disease, PET tracer synthesis, Β-amyloid plaque imaging",

author = "Yao, \{Cheng Hsiang\} and Lin, \{Kun Ju\} and Weng, \{Chi Chang\} and Hsiao, \{Ing Tsung\} and Ting, \{Yi Shu\} and Yen, \{Tzu Chen\} and Jan, \{Tong Rong\} and Daniel Skovronsky and Kung, \{Mei Ping\} and Wey, \{Shiaw Pyng\}",

year = "2010",

month = dec,

doi = "10.1016/j.apradiso.2010.07.001",

language = "英语",

volume = "68",

pages = "2293--2297",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

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}

TY - JOUR

T1 - GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging Β-amyloid plaques in human brain

AU - Yao, Cheng Hsiang

AU - Lin, Kun Ju

AU - Weng, Chi Chang

AU - Hsiao, Ing Tsung

AU - Ting, Yi Shu

AU - Yen, Tzu Chen

AU - Jan, Tong Rong

AU - Skovronsky, Daniel

AU - Kung, Mei Ping

AU - Wey, Shiaw Pyng

PY - 2010/12

Y1 - 2010/12

N2 - We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of 18F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of Β-amyloid (AΒ) plaques in the brain of Alzheimer's disease patients. [18F]AV-45 was prepared in 105min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4±7.7% with a final radiochemical purity of 95.3±2.2% (n=19). The specific activity of [18F]AV-45 reached as high as 470±135TBq/mmol (n=19). The present studies show that [18F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.

AB - We report herein the Good Manufacturing Practice (GMP)-compliant automated synthesis of 18F-labeled styrylpyridine, AV-45 (Florbetapir), a novel tracer for positron emission tomography (PET) imaging of Β-amyloid (AΒ) plaques in the brain of Alzheimer's disease patients. [18F]AV-45 was prepared in 105min using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions. The overall yield was 25.4±7.7% with a final radiochemical purity of 95.3±2.2% (n=19). The specific activity of [18F]AV-45 reached as high as 470±135TBq/mmol (n=19). The present studies show that [18F]AV-45 can be manufactured under GMP-compliant conditions and could be widely available for routine clinical use.

KW - Alzheimer's disease

KW - PET tracer synthesis

KW - Β-amyloid plaque imaging

UR - https://www.scopus.com/pages/publications/77956412778

U2 - 10.1016/j.apradiso.2010.07.001

DO - 10.1016/j.apradiso.2010.07.001

M3 - 文章

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AN - SCOPUS:77956412778

SN - 0969-8043

VL - 68

SP - 2293

EP - 2297

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 12

ER -