@inproceedings{5b1427edbba6404ca6ff9b9194d6b056,
title = "Gold nanoparticle-based redox signal enhancement towards the detection of single bacterium",
abstract = "In this work, we report a portable microfluidic chip based on gold nanoparticle-enhanced electrochemical detection for single-bacteria diognostic. The possibility of single-bacteria detection is realized here by using electroactive molecules modified on gold nanoparticles (NPs) to detect and differentiate Staphylococcus aureus and Pseudomonas aeruginosa. The detection limit of these two electroactive molecules is near femtomolar (1 pM) when immobilized on gold nanoparticles (NPs), and the minima amounts of gold NPs required in the detection is around thousands (103 particle/l). A concentration of couples whole bacteria (<10 cells/l) is detected by CV measurements. The liner detection limit concention is form 1-1000 cells/μl. The results showed that the portable biochip system has great potential as a device for single-particle or possibly even single-organism detection.",
author = "Wu, {Jen Kuei} and Chang, {Hwan You} and Tseng, {Fan Gang}",
year = "2011",
doi = "10.1109/TRANSDUCERS.2011.5969346",
language = "英语",
isbn = "9781457701573",
series = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",
pages = "2758--2761",
booktitle = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",
note = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 ; Conference date: 05-06-2011 Through 09-06-2011",
}