Gold nanoparticles presenting hybridized self-assembled aptamers that exhibit enhanced inhibition of thrombin

Yen Chun Shiang; Chia Lun Hsu; Chih Ching Huang; Huan Tsung Chang

doi:10.1002/anie.201101718

Gold nanoparticles presenting hybridized self-assembled aptamers that exhibit enhanced inhibition of thrombin

Yen Chun Shiang^*
, Chia Lun Hsu
, Chih Ching Huang
, Huan Tsung Chang

^*Corresponding author for this work

National Taiwan University
National Taiwan Ocean University

Research output: Contribution to journal › Journal Article › peer-review

43 Scopus citations

Abstract

DNA hybridization of thrombin-binding aptamers (TBAs) to form a self-assembled arranged monolayer on gold nanoparticles (AuNPs) was used to control the coagulation activity of thrombin. The hTBA ₁₅/hTBA ₂₉/cDNA-AuNPs provided flexibility and a suitable orientation and distance between the hTBA ₁₅ and hTBA ₂₉ units for bivalent binding, allowing strong interactions with thrombin and extremely high anticoagulant potency.

Original language	English
Pages (from-to)	7660-7665
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	33
DOIs	https://doi.org/10.1002/anie.201101718
State	Published - 08 08 2011
Externally published	Yes

Keywords

aptamers
enzyme activity
gold
nanoparticles
thrombin

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10.1002/anie.201101718

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abstract = "DNA hybridization of thrombin-binding aptamers (TBAs) to form a self-assembled arranged monolayer on gold nanoparticles (AuNPs) was used to control the coagulation activity of thrombin. The hTBA 15/hTBA 29/cDNA-AuNPs provided flexibility and a suitable orientation and distance between the hTBA 15 and hTBA 29 units for bivalent binding, allowing strong interactions with thrombin and extremely high anticoagulant potency.",

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AU - Shiang, Yen Chun

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AU - Huang, Chih Ching

AU - Chang, Huan Tsung

PY - 2011/8/8

Y1 - 2011/8/8

N2 - DNA hybridization of thrombin-binding aptamers (TBAs) to form a self-assembled arranged monolayer on gold nanoparticles (AuNPs) was used to control the coagulation activity of thrombin. The hTBA 15/hTBA 29/cDNA-AuNPs provided flexibility and a suitable orientation and distance between the hTBA 15 and hTBA 29 units for bivalent binding, allowing strong interactions with thrombin and extremely high anticoagulant potency.

AB - DNA hybridization of thrombin-binding aptamers (TBAs) to form a self-assembled arranged monolayer on gold nanoparticles (AuNPs) was used to control the coagulation activity of thrombin. The hTBA 15/hTBA 29/cDNA-AuNPs provided flexibility and a suitable orientation and distance between the hTBA 15 and hTBA 29 units for bivalent binding, allowing strong interactions with thrombin and extremely high anticoagulant potency.

KW - aptamers

KW - enzyme activity

KW - gold

KW - nanoparticles

KW - thrombin

UR - https://www.scopus.com/pages/publications/79961224814

U2 - 10.1002/anie.201101718

DO - 10.1002/anie.201101718

M3 - 文章

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AN - SCOPUS:79961224814

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ER -

Gold nanoparticles presenting hybridized self-assembled aptamers that exhibit enhanced inhibition of thrombin

Abstract

Keywords

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