Granulosa-lutein cell growth differentiation factor-9 (GDF-9) messenger RNA and protein expression in in vitro fertilization (IVF) cycles: relation to characteristics of ovulation induction and IVF

Hong Yuan Huang*, Hsin Shih Wang, She Hung Chan, Chyi Long Lee, Chia Woei Wang, Yung Kuei Soong

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

7 Scopus citations

Abstract

Granulosa-lutein cell growth differentiation factor-9 (GDF-9), a member of the transforming growth factor β (TGF-β) superfamily, is an oocyte-derived factor expressed throughout the development of the maturing follicle and is essential in early follicular development and fertility. Both GDF-9 messenger RNA and protein are detected in granulosa-lutein cells. A statistically significant correlation between GDF-9 expression and the number of dominant follicles on the day human chorionic gonadotropin is administered also is demonstrated. Human granulosa-lutein cell GDF-9 expression may play a role in folliculogenesis dependent on follicle-stimulating hormone in the in vitro fertilization cycle.

Original languageEnglish
Pages (from-to)1583-1585
Number of pages3
JournalFertility and Sterility
Volume91
Issue number4 SUPPL.
DOIs
StatePublished - 04 2009
Externally publishedYes

Keywords

  • GDF-9
  • PCR
  • folliculogenesis
  • granulosa cell
  • in vitro fertilization
  • oocyte

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