Abstract
Granulosa-lutein cell growth differentiation factor-9 (GDF-9), a member of the transforming growth factor β (TGF-β) superfamily, is an oocyte-derived factor expressed throughout the development of the maturing follicle and is essential in early follicular development and fertility. Both GDF-9 messenger RNA and protein are detected in granulosa-lutein cells. A statistically significant correlation between GDF-9 expression and the number of dominant follicles on the day human chorionic gonadotropin is administered also is demonstrated. Human granulosa-lutein cell GDF-9 expression may play a role in folliculogenesis dependent on follicle-stimulating hormone in the in vitro fertilization cycle.
Original language | English |
---|---|
Pages (from-to) | 1583-1585 |
Number of pages | 3 |
Journal | Fertility and Sterility |
Volume | 91 |
Issue number | 4 SUPPL. |
DOIs | |
State | Published - 04 2009 |
Externally published | Yes |
Keywords
- GDF-9
- PCR
- folliculogenesis
- granulosa cell
- in vitro fertilization
- oocyte