Growth inhibitors against tumor cells in cordyceps sinensis other than cordycepin and polysaccharides

Yuh Chi Kuo; Ching Yuang Lin; Wei Jern Tsai; Chia Ling Wu; Chieh Fu Chen; Ming Shi Shiao

doi:10.3109/07357909409023046

Growth inhibitors against tumor cells in cordyceps sinensis other than cordycepin and polysaccharides

Yuh Chi Kuo^*, Ching Yuang Lin, Wei Jern Tsai, Chia Ling Wu, Chieh Fu Chen, Ming Shi Shiao

^*Corresponding author for this work

Veterans General Hospital-Taipei

Research output: Contribution to journal › Journal Article › peer-review

95 Scopus citations

Abstract

Cordyceps sinensis is a parasitic fungus that has been used as a Chinese medicine for a long time. In the present study, inhibitory effects of crude methanolic extracts of C. sinensis fruiting bodies on various tumor cell lines were demonstrated. The crude methanolic extracts were fractionated into 15 fractions by silica gel column chromatography. Two of the 15 fractions (CS-36-39 and CS-48-51) significantly inhibited the growth of K562, Vero, Wish, Calu-1, and Raji tumor cell lines. The inhibitory activities were not due to the polysaccharides, which have been removed in the extracting process. The polarities of these two fractions indicated that they were different from that of cordycepin. Therefore, it is suggested that tumor cell growth inhibitors, other than cordycepin and polysaccharides, are contained in C. sinensis.

Original language	English
Pages (from-to)	611-615
Number of pages	5
Journal	Cancer Investigation
Volume	12
Issue number	6
DOIs	https://doi.org/10.3109/07357909409023046
State	Published - 1994
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3109/07357909409023046

Cite this

@article{f08605aa6e294b51b565ad85b01ca7bd,

title = "Growth inhibitors against tumor cells in cordyceps sinensis other than cordycepin and polysaccharides",

abstract = "Cordyceps sinensis is a parasitic fungus that has been used as a Chinese medicine for a long time. In the present study, inhibitory effects of crude methanolic extracts of C. sinensis fruiting bodies on various tumor cell lines were demonstrated. The crude methanolic extracts were fractionated into 15 fractions by silica gel column chromatography. Two of the 15 fractions (CS-36-39 and CS-48-51) significantly inhibited the growth of K562, Vero, Wish, Calu-1, and Raji tumor cell lines. The inhibitory activities were not due to the polysaccharides, which have been removed in the extracting process. The polarities of these two fractions indicated that they were different from that of cordycepin. Therefore, it is suggested that tumor cell growth inhibitors, other than cordycepin and polysaccharides, are contained in C. sinensis.",

author = "Kuo, {Yuh Chi} and Lin, {Ching Yuang} and Tsai, {Wei Jern} and Wu, {Chia Ling} and Chen, {Chieh Fu} and Shiao, {Ming Shi}",

year = "1994",

doi = "10.3109/07357909409023046",

language = "英语",

volume = "12",

pages = "611--615",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Informa Healthcare",

number = "6",

}

TY - JOUR

T1 - Growth inhibitors against tumor cells in cordyceps sinensis other than cordycepin and polysaccharides

AU - Kuo, Yuh Chi

AU - Lin, Ching Yuang

AU - Tsai, Wei Jern

AU - Wu, Chia Ling

AU - Chen, Chieh Fu

AU - Shiao, Ming Shi

PY - 1994

Y1 - 1994

N2 - Cordyceps sinensis is a parasitic fungus that has been used as a Chinese medicine for a long time. In the present study, inhibitory effects of crude methanolic extracts of C. sinensis fruiting bodies on various tumor cell lines were demonstrated. The crude methanolic extracts were fractionated into 15 fractions by silica gel column chromatography. Two of the 15 fractions (CS-36-39 and CS-48-51) significantly inhibited the growth of K562, Vero, Wish, Calu-1, and Raji tumor cell lines. The inhibitory activities were not due to the polysaccharides, which have been removed in the extracting process. The polarities of these two fractions indicated that they were different from that of cordycepin. Therefore, it is suggested that tumor cell growth inhibitors, other than cordycepin and polysaccharides, are contained in C. sinensis.

AB - Cordyceps sinensis is a parasitic fungus that has been used as a Chinese medicine for a long time. In the present study, inhibitory effects of crude methanolic extracts of C. sinensis fruiting bodies on various tumor cell lines were demonstrated. The crude methanolic extracts were fractionated into 15 fractions by silica gel column chromatography. Two of the 15 fractions (CS-36-39 and CS-48-51) significantly inhibited the growth of K562, Vero, Wish, Calu-1, and Raji tumor cell lines. The inhibitory activities were not due to the polysaccharides, which have been removed in the extracting process. The polarities of these two fractions indicated that they were different from that of cordycepin. Therefore, it is suggested that tumor cell growth inhibitors, other than cordycepin and polysaccharides, are contained in C. sinensis.

UR - http://www.scopus.com/inward/record.url?scp=0027945149&partnerID=8YFLogxK

U2 - 10.3109/07357909409023046

DO - 10.3109/07357909409023046

M3 - 文章

C2 - 7994596

AN - SCOPUS:0027945149

SN - 0735-7907

VL - 12

SP - 611

EP - 615

JO - Cancer Investigation

JF - Cancer Investigation

IS - 6

ER -

Growth inhibitors against tumor cells in cordyceps sinensis other than cordycepin and polysaccharides

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this