G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan

Ying Ju Lin; Lei Wan; Jim Jinn Chyuan Sheu; Chung Ming Huang; Cheng Wen Lin; Yu Ching Lan; Chih Ho Lai; Chien Hui Hung; Yuhsin Tsai; Chang Hai Tsai; Wei Yong Lin; Hsin Ping Liu; Ting Hsu Lin; Yu Min Huang; Fuu Jen Tsai

doi:10.1016/j.clim.2008.05.011

G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan

Ying Ju Lin, Lei Wan, Jim Jinn Chyuan Sheu, Chung Ming Huang, Cheng Wen Lin, Yu Ching Lan, Chih Ho Lai, Chien Hui Hung, Yuhsin Tsai, Chang Hai Tsai, Wei Yong Lin, Hsin Ping Liu, Ting Hsu Lin, Yu Min Huang, Fuu Jen Tsai^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

12 Scopus citations

Abstract

Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10^{- 14}; OR = 3.94; 95% CI = 2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95% CI = 1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95% CI = 0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. Crown

Original language	English
Pages (from-to)	36-39
Number of pages	4
Journal	Clinical Immunology
Volume	129
Issue number	1
DOIs	https://doi.org/10.1016/j.clim.2008.05.011
State	Published - 10 2008
Externally published	Yes

Keywords

Interleukin-2
Single nucleotide polymorphism
Systemic lupus erythematosus

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10.1016/j.clim.2008.05.011

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Lin, Y. J., Wan, L., Sheu, J. J. C., Huang, C. M., Lin, C. W., Lan, Y. C., Lai, C. H., Hung, C. H., Tsai, Y., Tsai, C. H., Lin, W. Y., Liu, H. P., Lin, T. H., Huang, Y. M., & Tsai, F. J. (2008). G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan. Clinical Immunology, 129(1), 36-39. https://doi.org/10.1016/j.clim.2008.05.011

@article{7dd5616dbfe648ada554930169211537,

title = "G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan",

abstract = "Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10- 14; OR = 3.94; 95% CI = 2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95% CI = 1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95% CI = 0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. Crown",

keywords = "Interleukin-2, Single nucleotide polymorphism, Systemic lupus erythematosus",

author = "Lin, {Ying Ju} and Lei Wan and Sheu, {Jim Jinn Chyuan} and Huang, {Chung Ming} and Lin, {Cheng Wen} and Lan, {Yu Ching} and Lai, {Chih Ho} and Hung, {Chien Hui} and Yuhsin Tsai and Tsai, {Chang Hai} and Lin, {Wei Yong} and Liu, {Hsin Ping} and Lin, {Ting Hsu} and Huang, {Yu Min} and Tsai, {Fuu Jen}",

year = "2008",

month = oct,

doi = "10.1016/j.clim.2008.05.011",

language = "英语",

volume = "129",

pages = "36--39",

journal = "Clinical Immunology",

issn = "1521-6616",

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T1 - G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan

AU - Lin, Ying Ju

AU - Wan, Lei

AU - Sheu, Jim Jinn Chyuan

AU - Huang, Chung Ming

AU - Lin, Cheng Wen

AU - Lan, Yu Ching

AU - Lai, Chih Ho

AU - Hung, Chien Hui

AU - Tsai, Yuhsin

AU - Tsai, Chang Hai

AU - Lin, Wei Yong

AU - Liu, Hsin Ping

AU - Lin, Ting Hsu

AU - Huang, Yu Min

AU - Tsai, Fuu Jen

PY - 2008/10

Y1 - 2008/10

N2 - Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10- 14; OR = 3.94; 95% CI = 2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95% CI = 1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95% CI = 0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. Crown

AB - Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10- 14; OR = 3.94; 95% CI = 2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95% CI = 1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95% CI = 0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. Crown

KW - Interleukin-2

KW - Single nucleotide polymorphism

KW - Systemic lupus erythematosus

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SN - 1521-6616

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EP - 39

JO - Clinical Immunology

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ER -

G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan

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Keywords

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