Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan

Jia Yu Chen; Chiung Yao Huang; Yun Sheng Lin; Tsong Long Hwang; Wei Lung Wang; Shu Fen Chiou; Jyh Horng Sheu

doi:10.1021/acs.jnatprod.6b00452

Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan

Jia Yu Chen, Chiung Yao Huang, Yun Sheng Lin, Tsong Long Hwang, Wei Lung Wang, Shu Fen Chiou, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

22 Scopus citations

Abstract

Chemical investigation of the red alga Laurencia tristicha led to the discovery of eight new halogenated chamigrane-type sesquiterpenoids (1-8) and one new bromocuparane-type sesquiterpene (9), along with nine known related metabolites (10-18). Their structures were elucidated on the basis of extensive spectroscopic analyses, and the absolute configurations of 1-8 were proposed by comparison to the biosynthetically related known compound 12. Cytotoxicity, antibacterial, and anti-inflammatory activities of these isolates were also investigated. The results showed that compound 11 exhibited good antibacterial activity against Serratia marcescens compared to the positive control ampicillin at a dosage of 100 μg/disk. Compound 17 showed strong inhibition toward elastase release generation at 10 μM.

Original language	English
Pages (from-to)	2315-2323
Number of pages	9
Journal	Journal of Natural Products
Volume	79
Issue number	9
DOIs	https://doi.org/10.1021/acs.jnatprod.6b00452
State	Published - 23 09 2016

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Publisher Copyright:
© 2016 The American Chemical Society and American Society of Pharmacognosy.

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title = "Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan",

abstract = "Chemical investigation of the red alga Laurencia tristicha led to the discovery of eight new halogenated chamigrane-type sesquiterpenoids (1-8) and one new bromocuparane-type sesquiterpene (9), along with nine known related metabolites (10-18). Their structures were elucidated on the basis of extensive spectroscopic analyses, and the absolute configurations of 1-8 were proposed by comparison to the biosynthetically related known compound 12. Cytotoxicity, antibacterial, and anti-inflammatory activities of these isolates were also investigated. The results showed that compound 11 exhibited good antibacterial activity against Serratia marcescens compared to the positive control ampicillin at a dosage of 100 μg/disk. Compound 17 showed strong inhibition toward elastase release generation at 10 μM.",

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note = "Publisher Copyright: {\textcopyright} 2016 The American Chemical Society and American Society of Pharmacognosy.",

year = "2016",

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doi = "10.1021/acs.jnatprod.6b00452",

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AU - Chen, Jia Yu

AU - Huang, Chiung Yao

AU - Lin, Yun Sheng

AU - Hwang, Tsong Long

AU - Wang, Wei Lung

AU - Chiou, Shu Fen

AU - Sheu, Jyh Horng

PY - 2016/9/23

Y1 - 2016/9/23

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AB - Chemical investigation of the red alga Laurencia tristicha led to the discovery of eight new halogenated chamigrane-type sesquiterpenoids (1-8) and one new bromocuparane-type sesquiterpene (9), along with nine known related metabolites (10-18). Their structures were elucidated on the basis of extensive spectroscopic analyses, and the absolute configurations of 1-8 were proposed by comparison to the biosynthetically related known compound 12. Cytotoxicity, antibacterial, and anti-inflammatory activities of these isolates were also investigated. The results showed that compound 11 exhibited good antibacterial activity against Serratia marcescens compared to the positive control ampicillin at a dosage of 100 μg/disk. Compound 17 showed strong inhibition toward elastase release generation at 10 μM.

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Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan

Abstract

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