Harnessing and honing mesenchymal stem/stromal cells for the amelioration of graft-versus-host disease

Tang Her Jaing*, Tsung Yen Chang, Chia Chi Chiu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Allogeneic hematopoietic stem cell transplantation is a deterministic curative procedure for various hematologic disorders and congenital immunodeficiency. Despite its increased use, the mortality rate for patients undergoing this procedure remains high, mainly due to the perceived risk of exacerbating graft-versus-host disease (GVHD). However, even with immunosuppressive agents, some patients still develop GVHD. Advanced mesenchymal stem/stromal cell (MSC) strategies have been proposed to achieve better therapeutic outcomes, given their immunosuppressive potential. However, the efficacy and trial designs have varied among the studies, and some research findings appear contradictory due to the challenges in characterizing the in vivo effects of MSCs. This review aims to provide real insights into this clinical entity, emphasizing diagnostic, and therapeutic considerations and generating pathophysiology hypotheses to identify research avenues. The indications and timing for the clinical application of MSCs are still subject to debate.

Original languageEnglish
Pages (from-to)221-234
Number of pages14
JournalWorld Journal of Stem Cells
Volume15
Issue number4
DOIs
StatePublished - 26 04 2023

Bibliographical note

©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

Keywords

  • Adaptive immunity
  • Exosomes
  • Graft-versus-host disease
  • Immunomodulatory
  • Mesenchymal stem/stromal cells

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