Heart failure enhances arrhythmogenesis in pulmonary veins

Shih Lin Chang, Yao Chang Chen, Yung Hsin Yeh, Yu Jun Lai, Hung I. Yeh, Cheng I. Lin, Yung Kuo Lin, Yenn Jiang Lin, Tsu Juey Wu, Yi Kung Huang, Shih Ann Chen, Yi Jen Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

18 Scopus citations


1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P<0.001) and high-frequency irregular electrical activity (92 vs 38%, P=0.01; 23±1 vs 19±1Hz, P=0.003), greater depolarized resting membrane potential (-59±1 vs -70±2mV, P<0.001), higher incidence of early afterdepolarizations (EAD; 69 vs 6%, P=0.001) and delayed afterdepolarizations (DAD; 92 vs 25%, P=0.001), and slower conduction velocity (38±2 vs 63±2cm/s, P<0.05). In comparison to the HF-LA, the HF-PV had a higher incidence of spontaneous activity and high-frequency irregular electrical activity (85 vs 39%, P=0.04; 92 vs 46%, P=0.03), and higher incidence of EAD and DAD, and those differences were not found between the control-LA and control-PV. The control-PV with high-frequency irregular electrical activity had a higher incidence of DAD and spontaneous activity as compared with those without it. 4.HF contributed to an increased automaticity, triggered activity and conduction disturbance in the PV. The PV possessed more arrhythmogenic properties, which might play an important role in the genesis of AF in HF.

Original languageEnglish
Pages (from-to)666-674
Number of pages9
JournalClinical and Experimental Pharmacology and Physiology
Issue number10
StatePublished - 10 2011
Externally publishedYes


  • Multi-electrode
  • Remodelling
  • Triggered activity


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