Heme oxygenase-1 mediates the anti-inflammatory effect of curcumin within LPS-stimulated human monocytes

Hsien Yeh Hsu*, Li Chieh Chu, Kuo Feng Hua, Louis Kuoping Chao

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

67 Scopus citations

Abstract

Curcumin, a polyphenolic compound derived from plant, regulates heme oxygenase (HO-1) expression within certain cell types; however, the Curcumin-mediated signal transduction in the regulation of HO-1 expression within human monocytes/macrophages is unclear. Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCα, PKCδ/ ERK1/2, p38α, and PI3-kinase, In addition, H2O2 release is essential for Curcumin-mediated ERK1/2 and p38 phosphorylation and HO-1 expression. Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion, HO-1 over-expression produced the same inhibitory effects of Curcumin on IL-1 secretion. Collectively, our results suggest that Curcumin inhibits cytokines secretion within LPS-stimulated monocytes through a mechanism that involves the action of HO-1.

Original languageEnglish
Pages (from-to)603-612
Number of pages10
JournalJournal of Cellular Physiology
Volume215
Issue number3
DOIs
StatePublished - 06 2008
Externally publishedYes

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