Hepatic Clostridium Perfringens Abscess Formation after Radiofrequency Ablation Therapy for Hepatocellular Carcinoma: Report of a Rare Case

Ming Hung Wang, Yuan Hung Kuo, Yi Hao Yen, Sheng Nan Lu, Jing Houng Wang, Chien Hung Chen, Chao Hung Hung, Kwong Ming Kee*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

2 Scopus citations

Abstract

Liver abscess formation is one of the major complications following radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC). Clostridium perfringens is a rare but fatal (mortality rate: 70-100%) organism that could lead to severe sepsis. We presented a case where a 63-year-old woman with diabetes mellitus, hypertension, chronic hepatitis B-related cirrhosis in Child-Pugh class A and HCC with initial TNM stage II who had undergone 2 sessions of transarterial chemoembolization. RFA was performed for 4 small HCC due to poor effect of previous transarterial chemoembolization. However, all 4 treated tumors developed liver abscesses presenting with septic shock within 1 day. Aspirated abscesses and blood culture both yielded C. perfringens infection. After intensive care, optimal intravenous antibiotic, and abscesses aspiration, the patient recovered successfully. All tumors achieved complete response during the follow-up period without local recurrence. The clinical presentations and risk factors of C. perfringens-related liver abscess after RFA will be discussed in this manuscript.

Original languageEnglish
Pages (from-to)906-911
Number of pages6
JournalCase Reports in Oncology
Volume14
Issue number2
DOIs
StatePublished - 17 06 2021

Bibliographical note

Publisher Copyright:
© 2021

Keywords

  • Clostridium perfringens
  • Hepatocellular carcinoma
  • Liver abscess
  • Radiofrequency ablation

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