Hepatocellular carcinoma surveillance at 4-vs. 12-month intervals for patients with chronic viral hepatitis: A randomized study in community

Jing Houng Wang, Kuo Chin Chang, Kwong Ming Kee, Pao Fei Chen, Yi Hao Yen, Po Lin Tseng, Yuan Hung Kuo, Ming Chao Tsai, Chao Hung Hung, Chien Hung Chen, Wei Chen Tai, Lin San Tsai, Shu Chuan Chen, Sheng Che Lin, Sheng Nan Lu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

61 Scopus citations

Abstract

OBJECTIVES:To compare the efficacy of hepatocellular carcinoma (HCC) surveillance at 4- and 12-month intervals in a community for patients with chronic viral hepatitis and thrombocytopenia.METHODS:In 10 townships, adults (≥40 years) with platelet ≤150 (×10 9)/l, positive hepatitis B surface antigen, or antibody to hepatitis C virus were invited to this study. These townships were randomized into 4- (group A) and 12-month (group B) interval surveillance groups. Seven hundred and eighty-five and 796 residents met the study criteria in groups A and B. Ultrasonography (US) was the surveillance method.RESULTS:A total of 744 residents (group A: 387; group B: 357) were enrolled. In the study period, HCC was diagnosed in 39 residents (group A: 24; group B: 15). There was no difference in cumulative 3-year HCC incidence between the two groups. The tumors were smaller in group A than in group B, though group A had more patients with tumor ≤2 cm (P=0.003) who were in Barcelona Clinic Liver Cancer (BCLC) very-early stage (P=0.017) and had undergone curative treatments (P=0.049). Male gender, cirrhosis, and platelet ≤100 (×10 9)/l were associated factors of HCC occurrence. There was no difference in 4-year overall survival between the two groups. Patients undergoing recommended treatments had better 4-year survival rates.CONCLUSIONS:Compared with 12-month interval, US surveillance at 4-month interval detected more patients with HCC≤ 2 cm who were in BCLC very-early stage and were fit for curative treatments. Up to 4-year follow-up, however, the overall survival was not different.

Original languageEnglish
Pages (from-to)416-424
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume108
Issue number3
DOIs
StatePublished - 03 2013

Fingerprint

Dive into the research topics of 'Hepatocellular carcinoma surveillance at 4-vs. 12-month intervals for patients with chronic viral hepatitis: A randomized study in community'. Together they form a unique fingerprint.

Cite this