Herpes simplex virus and pterygium in Taiwan

Yeong Fong Chen; Ching Hsi Hsiao; Kah Wai Ngan; Ling Yeung; Hsin Yuan Tan; Kai Hsiang Yang; Samuel Chao Ming Huang; Ken Kuo Lin

doi:10.1097/ICO.0b013e31815ca667

Herpes simplex virus and pterygium in Taiwan

Yeong Fong Chen^*, Ching Hsi Hsiao, Kah Wai Ngan, Ling Yeung, Hsin Yuan Tan, Kai Hsiang Yang, Samuel Chao Ming Huang, Ken Kuo Lin

^*Corresponding author for this work

Department of Public Health

Research output: Contribution to journal › Journal Article › peer-review

12 Scopus citations

Abstract

PURPOSE: To evaluate the presence of herpes simplex virus (HSV) in pterygia to study the possible association between HSV and pterygia in Taiwan, a tropical country with a high prevalence of pterygium. METHODS: Sixty-five pterygia, 10 normal conjunctiva, 8 conjunctival nevi, and 2 malignant conjunctival melanomas were obtained. Clinical histories were recorded for each patient. HSV detection was accomplished by polymerase chain reaction amplification of viral sequences. HSV-positive specimens underwent subsequent DNA in situ hybridization. Results were statistically analyzed. RESULTS: By using polymerase chain reaction, HSV was detected in 3 (5%) pterygia, and no conjunctival control displayed HSV. All 3 HSV-positive pterygia studies were DNA in situ hybridization negative. There was no statistically significant correlation between pterygium and the presence of HSV. CONCLUSIONS: HSV is not associated with pterygium formation in Taiwan; the pathogenesis of pterygia is still incompletely understood.

Original language	English
Pages (from-to)	311-313
Number of pages	3
Journal	Cornea
Volume	27
Issue number	3
DOIs	https://doi.org/10.1097/ICO.0b013e31815ca667
State	Published - 04 2008

Keywords

Herpes simplex virus
Pterygium

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title = "Herpes simplex virus and pterygium in Taiwan",

abstract = "PURPOSE: To evaluate the presence of herpes simplex virus (HSV) in pterygia to study the possible association between HSV and pterygia in Taiwan, a tropical country with a high prevalence of pterygium. METHODS: Sixty-five pterygia, 10 normal conjunctiva, 8 conjunctival nevi, and 2 malignant conjunctival melanomas were obtained. Clinical histories were recorded for each patient. HSV detection was accomplished by polymerase chain reaction amplification of viral sequences. HSV-positive specimens underwent subsequent DNA in situ hybridization. Results were statistically analyzed. RESULTS: By using polymerase chain reaction, HSV was detected in 3 (5%) pterygia, and no conjunctival control displayed HSV. All 3 HSV-positive pterygia studies were DNA in situ hybridization negative. There was no statistically significant correlation between pterygium and the presence of HSV. CONCLUSIONS: HSV is not associated with pterygium formation in Taiwan; the pathogenesis of pterygia is still incompletely understood.",

keywords = "Herpes simplex virus, Pterygium",

author = "Chen, {Yeong Fong} and Hsiao, {Ching Hsi} and Ngan, {Kah Wai} and Ling Yeung and Tan, {Hsin Yuan} and Yang, {Kai Hsiang} and Huang, {Samuel Chao Ming} and Lin, {Ken Kuo}",

year = "2008",

month = apr,

doi = "10.1097/ICO.0b013e31815ca667",

language = "英语",

volume = "27",

pages = "311--313",

journal = "Cornea",

issn = "0277-3740",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Herpes simplex virus and pterygium in Taiwan

AU - Chen, Yeong Fong

AU - Hsiao, Ching Hsi

AU - Ngan, Kah Wai

AU - Yeung, Ling

AU - Tan, Hsin Yuan

AU - Yang, Kai Hsiang

AU - Huang, Samuel Chao Ming

AU - Lin, Ken Kuo

PY - 2008/4

Y1 - 2008/4

N2 - PURPOSE: To evaluate the presence of herpes simplex virus (HSV) in pterygia to study the possible association between HSV and pterygia in Taiwan, a tropical country with a high prevalence of pterygium. METHODS: Sixty-five pterygia, 10 normal conjunctiva, 8 conjunctival nevi, and 2 malignant conjunctival melanomas were obtained. Clinical histories were recorded for each patient. HSV detection was accomplished by polymerase chain reaction amplification of viral sequences. HSV-positive specimens underwent subsequent DNA in situ hybridization. Results were statistically analyzed. RESULTS: By using polymerase chain reaction, HSV was detected in 3 (5%) pterygia, and no conjunctival control displayed HSV. All 3 HSV-positive pterygia studies were DNA in situ hybridization negative. There was no statistically significant correlation between pterygium and the presence of HSV. CONCLUSIONS: HSV is not associated with pterygium formation in Taiwan; the pathogenesis of pterygia is still incompletely understood.

AB - PURPOSE: To evaluate the presence of herpes simplex virus (HSV) in pterygia to study the possible association between HSV and pterygia in Taiwan, a tropical country with a high prevalence of pterygium. METHODS: Sixty-five pterygia, 10 normal conjunctiva, 8 conjunctival nevi, and 2 malignant conjunctival melanomas were obtained. Clinical histories were recorded for each patient. HSV detection was accomplished by polymerase chain reaction amplification of viral sequences. HSV-positive specimens underwent subsequent DNA in situ hybridization. Results were statistically analyzed. RESULTS: By using polymerase chain reaction, HSV was detected in 3 (5%) pterygia, and no conjunctival control displayed HSV. All 3 HSV-positive pterygia studies were DNA in situ hybridization negative. There was no statistically significant correlation between pterygium and the presence of HSV. CONCLUSIONS: HSV is not associated with pterygium formation in Taiwan; the pathogenesis of pterygia is still incompletely understood.

KW - Herpes simplex virus

KW - Pterygium

UR - http://www.scopus.com/inward/record.url?scp=41149108659&partnerID=8YFLogxK

U2 - 10.1097/ICO.0b013e31815ca667

DO - 10.1097/ICO.0b013e31815ca667

M3 - 文章

C2 - 18362659

AN - SCOPUS:41149108659

SN - 0277-3740

VL - 27

SP - 311

EP - 313

JO - Cornea

JF - Cornea

IS - 3

ER -

Herpes simplex virus and pterygium in Taiwan

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Keywords

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