Heterodyne interferometric surface plasmon resonance biosensor

Shen Fen Joe, Li Zen Hsieh*, Liann Be Chang, Chih Chung Hsieh, Chien Ming Wu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations


A high-sensitivity surface plasmon resonance (SPR) biosensor is constructed by using a common-path heterodyne interferometric system. The beam combiner is employed to combine the modulated He-Ne TE-wave and TM-wave into a heterodyne light source with a frequency difference of 60 kHz. Using the common-path heterodyne interferometric system to obtain the phase shift between the two waves has the advantage of high-sensitivity real-time phase detection for monitoring molecular interactions. By detecting the phase shift, the proposed SPR biosensor is employed to monitor the interactions between the sheep IgG covalently immobilized on the sensor chip surface and the anti-sheep IgG contained in the running buffer.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalJournal of Medical and Biological Engineering
Issue number4
StatePublished - 12 2006


  • Biosensor
  • Heterodyne interferometry
  • Surface Plasmon Resonance


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