High body mass index reduces glomerular filtration rate decline in type II diabetes mellitus patients with stage 3 or 4 chronic kidney disease

Wen Hung Huang, Chao Yu Chen, Ja-Liang Lin, Dan Tzu Lin-Tan, Ching Wei Hsu, Tzung Hai Yen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

28 Scopus citations

Abstract

Whether high body mass index (BMI) has an effect on progressive diabetic nephropathy in type II diabetes mellitus (DM) patients with chronic kidney disease (CKD) stage 3 or 4 remains unclear. This prospective study aimed to investigate the relationship between BMI and progression of renal function deterioration in type II DM patients with CKD stage 3 or 4.A total of 105 type II DM patients with CKD stage 3 or 4 participated in this 24-month prospective observational study. Patients were divided into 3 groups according to BMI as follows: normal group, BMI of 18.5-22.9kg/m; overweight group, BMI of 23-24.9kg/m; and obese group, BMI of 25kg/m. The primary end point was a 2-fold elevation in serum creatinine levels (measured twice with a 1-month interval) from baseline values, need for long-term dialysis, or death during the 24-month observation period.In the linear regression analysis with the stepwise method, each 1kg/m increase in BMI led to an increase of 0.32mLmin×1.73m in the estimated glomerular filtration rate (95% confidence interval, CI, 0.01-0.62; P=0.04) during the 24-month study period. Moreover, multivariate Cox regression analysis showed that compared with the obese group, the normal BMI group (hazard ratio=2.76, 95% CI:1.27-6; P=0.01) achieved the primary outcome after adjusting for other factors.In this 24-month prospective observational study, we showed that BMI of 25kg/m was a protective factor for renal function deterioration in type II DM patients with CKD stage 3 or 4.

Original languageEnglish
Pages (from-to)e41
JournalMedicine (United States)
Volume93
Issue number7
DOIs
StatePublished - 08 2014
Externally publishedYes

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