@inproceedings{98b5a059481e434c8141e5d87f295f2c,
title = "High-density 3D nanostructured pillar arrays of Surface Enhanced Raman Scattering (SERS) biosensor for single bacteria detection by local electrokinetic trapping",
abstract = "Early diagnosis of bacterial infection is the key for improved survival by prompt and adequate antibiotic in the first few hours (2-3 hours) of infection. In this work, we demonstrate a possibility to rapid detection several pathogenic bacteria from blood plasma in 30 mins. Using modified gold nanoparticle enlarge Surface Enhanced Raman Scattering (SERS) on a High-Density 3D nanostructured Au/Si-pillar arrays platform (10-12 array/μm2) combined with AC electroosmoic (ACEO) trapping. ACEO and corresponding electrostatic force contributed to the binding affinity and reduce the diffusion time. The limit of detection could be lowered to 1-5 cells/ml detected by SERS measurements. The dynamic range of the sensor system ranged from 102-106 cells/mL. The results showed that the portable biochip system has great potential as a device for single-particle or possibly even single-organism detection.",
keywords = "AC electroosmoic (ACEO) trapping, Au/Si nanopillar arrays, SERS biosensor",
author = "Wu, {Jen Kuei} and Lee, {Chun Wei} and Kuo, {Teng Feng} and Chang, {Hwan You} and Tseng, {Fan Gang}",
year = "2013",
language = "英语",
isbn = "9781632666246",
series = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
publisher = "Chemical and Biological Microsystems Society",
pages = "1484--1486",
booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 ; Conference date: 27-10-2013 Through 31-10-2013",
}