High-frequency spinal cord stimulation treatment attenuates the increase in spinal glutamate release and spinal miniature excitatory postsynaptic currents in rats with spared nerve injury-induced neuropathic pain

Wen Tzu Liao; Chia Chih Tseng; Wan Ting Chia; Chung Ren Lin

doi:10.1016/j.brainresbull.2020.09.005

High-frequency spinal cord stimulation treatment attenuates the increase in spinal glutamate release and spinal miniature excitatory postsynaptic currents in rats with spared nerve injury-induced neuropathic pain

Wen Tzu Liao, Chia Chih Tseng, Wan Ting Chia, Chung Ren Lin^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

10 Scopus citations

Abstract

High-frequency spinal cord stimulation (HFSCS) at 10 kHz provides paresthesia-free treatment for chronic pain. However, the underlying mechanisms of its action have not been fully elucidated. The aim of the present study was to investigate the effect of HFSCS treatment on spinal glutamate release and uptake in spared nerve injury (SNI) rats. HFSCS was applied to the T10/T11 spinal cord 3 days after SNI. The concentration of spinal glutamate, glutamate transporter activity and miniature excitatory postsynaptic currents (mEPSCs) from neurons in lamina II were evaluated. HFSCS treatment alleviated SNI pain induced by mechanical and cold allodynia. HFSCS treatment also partially restored altered spinal glutamate uptake activity, the levels of spinal glutamate, and the frequency of mEPSCs following SNI. In conclusion, HFSCS treatment attenuated SNI-induced neuropathic pain and partially restored the altered glutamate uptake after SNI.

Original language	English
Pages (from-to)	307-313
Number of pages	7
Journal	Brain Research Bulletin
Volume	164
DOIs	https://doi.org/10.1016/j.brainresbull.2020.09.005
State	Published - 11 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

Electrophysiology
Excitatory amino acid
Microdialysis
Neuropathic pain
Spared nerve injury

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title = "High-frequency spinal cord stimulation treatment attenuates the increase in spinal glutamate release and spinal miniature excitatory postsynaptic currents in rats with spared nerve injury-induced neuropathic pain",

abstract = "High-frequency spinal cord stimulation (HFSCS) at 10 kHz provides paresthesia-free treatment for chronic pain. However, the underlying mechanisms of its action have not been fully elucidated. The aim of the present study was to investigate the effect of HFSCS treatment on spinal glutamate release and uptake in spared nerve injury (SNI) rats. HFSCS was applied to the T10/T11 spinal cord 3 days after SNI. The concentration of spinal glutamate, glutamate transporter activity and miniature excitatory postsynaptic currents (mEPSCs) from neurons in lamina II were evaluated. HFSCS treatment alleviated SNI pain induced by mechanical and cold allodynia. HFSCS treatment also partially restored altered spinal glutamate uptake activity, the levels of spinal glutamate, and the frequency of mEPSCs following SNI. In conclusion, HFSCS treatment attenuated SNI-induced neuropathic pain and partially restored the altered glutamate uptake after SNI.",

keywords = "Electrophysiology, Excitatory amino acid, Microdialysis, Neuropathic pain, Spared nerve injury",

author = "Liao, {Wen Tzu} and Tseng, {Chia Chih} and Chia, {Wan Ting} and Lin, {Chung Ren}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = nov,

doi = "10.1016/j.brainresbull.2020.09.005",

language = "英语",

volume = "164",

pages = "307--313",

journal = "Brain Research Bulletin",

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High-frequency spinal cord stimulation treatment attenuates the increase in spinal glutamate release and spinal miniature excitatory postsynaptic currents in rats with spared nerve injury-induced neuropathic pain. / Liao, Wen Tzu; Tseng, Chia Chih; Chia, Wan Ting et al.
In: Brain Research Bulletin, Vol. 164, 11.2020, p. 307-313.

Research output: Contribution to journal › Journal Article › peer-review

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AU - Liao, Wen Tzu

AU - Tseng, Chia Chih

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AU - Lin, Chung Ren

PY - 2020/11

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KW - Electrophysiology

KW - Excitatory amino acid

KW - Microdialysis

KW - Neuropathic pain

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High-frequency spinal cord stimulation treatment attenuates the increase in spinal glutamate release and spinal miniature excitatory postsynaptic currents in rats with spared nerve injury-induced neuropathic pain

Abstract

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Keywords

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