High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma

Cheng En Hsieh; Chia Yen Hung; Chien Yu Lin; Jiun Sheng Chen; Kai Ping Chang; Sathvik Panambur Aithala; Li Yu Lee; Ngan Ming Tsang; Chang Hsien Lu; Miao Fen Chen; Yu Fan Cheng; Kun Yun Yeh; Cheng Hsu Wang; Wen Chi Chou

doi:10.1002/hed.25603

High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma

Cheng En Hsieh, Chia Yen Hung, Chien Yu Lin, Jiun Sheng Chen, Kai Ping Chang, Sathvik Panambur Aithala, Li Yu Lee, Ngan Ming Tsang, Chang Hsien Lu, Miao Fen Chen, Yu Fan Cheng, Kun Yun Yeh, Cheng Hsu Wang, Wen Chi Chou^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

13 Scopus citations

Abstract

Background: The prognostic relevance of extranodal extension (ENE) for salivary gland carcinoma (SGC) remains unclear. The present study is undertaken to investigate the predictive significance of pathological nodal parameters in surgically treated patients with nodal metastatic SGC. Methods: This multicenter cohort included 114 patients with pathologically proven node-positive SGC between 2000 and 2014. Possible correlations of clinicopathological parameters and outcomes were examined. Results: The median follow-up was 69 months (range, 11-173 months). The multivariate analysis identified metastatic node number (1-2 vs 3-6; 1-2 vs ≥7) as an independent predictor for regional control (P = 0.005; P = 0.02), locoregional control (P = 0.008; P = 0.04), distant metastasis-free survival (P = 0.17; P = 0.006), disease-free survival (P = 0.05; P = 0.002), and overall survival (P = 0.18; P = 0.009), whereas ENE was not associated with survival outcomes. Conclusions: Metastatic node number, not ENE, is an independent node-related prognosticator for SGC. Integration of ENE into the American Joint Committee on Cancer 8th edition staging criteria may not improve prognostic performance.

Original language	English
Pages (from-to)	1572-1582
Number of pages	11
Journal	Head and Neck
Volume	41
Issue number	6
DOIs	https://doi.org/10.1002/hed.25603
State	Published - 06 2019

Bibliographical note

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

Keywords

AJCC stage
N classification
adjuvant radiotherapy
extracapsular spread
neck dissection
number of positive nodes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.25603

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Hsieh, C. E., Hung, C. Y., Lin, C. Y., Chen, J. S., Chang, K. P., Aithala, S. P., Lee, L. Y., Tsang, N. M., Lu, C. H., Chen, M. F., Cheng, Y. F., Yeh, K. Y., Wang, C. H., & Chou, W. C. (2019). High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma. Head and Neck, 41(6), 1572-1582. https://doi.org/10.1002/hed.25603

@article{53087a4e030b47d8b6da3543619d886f,

title = "High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma",

abstract = "Background: The prognostic relevance of extranodal extension (ENE) for salivary gland carcinoma (SGC) remains unclear. The present study is undertaken to investigate the predictive significance of pathological nodal parameters in surgically treated patients with nodal metastatic SGC. Methods: This multicenter cohort included 114 patients with pathologically proven node-positive SGC between 2000 and 2014. Possible correlations of clinicopathological parameters and outcomes were examined. Results: The median follow-up was 69 months (range, 11-173 months). The multivariate analysis identified metastatic node number (1-2 vs 3-6; 1-2 vs ≥7) as an independent predictor for regional control (P = 0.005; P = 0.02), locoregional control (P = 0.008; P = 0.04), distant metastasis-free survival (P = 0.17; P = 0.006), disease-free survival (P = 0.05; P = 0.002), and overall survival (P = 0.18; P = 0.009), whereas ENE was not associated with survival outcomes. Conclusions: Metastatic node number, not ENE, is an independent node-related prognosticator for SGC. Integration of ENE into the American Joint Committee on Cancer 8th edition staging criteria may not improve prognostic performance.",

keywords = "AJCC stage, N classification, adjuvant radiotherapy, extracapsular spread, neck dissection, number of positive nodes",

author = "Hsieh, {Cheng En} and Hung, {Chia Yen} and Lin, {Chien Yu} and Chen, {Jiun Sheng} and Chang, {Kai Ping} and Aithala, {Sathvik Panambur} and Lee, {Li Yu} and Tsang, {Ngan Ming} and Lu, {Chang Hsien} and Chen, {Miao Fen} and Cheng, {Yu Fan} and Yeh, {Kun Yun} and Wang, {Cheng Hsu} and Chou, {Wen Chi}",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = jun,

doi = "10.1002/hed.25603",

language = "英语",

volume = "41",

pages = "1572--1582",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "6",

}

Hsieh, CE, Hung, CY, Lin, CY, Chen, JS, Chang, KP, Aithala, SP, Lee, LY, Tsang, NM, Lu, CH, Chen, MF, Cheng, YF, Yeh, KY, Wang, CH & Chou, WC 2019, 'High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma', Head and Neck, vol. 41, no. 6, pp. 1572-1582. https://doi.org/10.1002/hed.25603

TY - JOUR

T1 - High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma

AU - Hsieh, Cheng En

AU - Hung, Chia Yen

AU - Lin, Chien Yu

AU - Chen, Jiun Sheng

AU - Chang, Kai Ping

AU - Aithala, Sathvik Panambur

AU - Lee, Li Yu

AU - Tsang, Ngan Ming

AU - Lu, Chang Hsien

AU - Chen, Miao Fen

AU - Cheng, Yu Fan

AU - Yeh, Kun Yun

AU - Wang, Cheng Hsu

AU - Chou, Wen Chi

PY - 2019/6

Y1 - 2019/6

N2 - Background: The prognostic relevance of extranodal extension (ENE) for salivary gland carcinoma (SGC) remains unclear. The present study is undertaken to investigate the predictive significance of pathological nodal parameters in surgically treated patients with nodal metastatic SGC. Methods: This multicenter cohort included 114 patients with pathologically proven node-positive SGC between 2000 and 2014. Possible correlations of clinicopathological parameters and outcomes were examined. Results: The median follow-up was 69 months (range, 11-173 months). The multivariate analysis identified metastatic node number (1-2 vs 3-6; 1-2 vs ≥7) as an independent predictor for regional control (P = 0.005; P = 0.02), locoregional control (P = 0.008; P = 0.04), distant metastasis-free survival (P = 0.17; P = 0.006), disease-free survival (P = 0.05; P = 0.002), and overall survival (P = 0.18; P = 0.009), whereas ENE was not associated with survival outcomes. Conclusions: Metastatic node number, not ENE, is an independent node-related prognosticator for SGC. Integration of ENE into the American Joint Committee on Cancer 8th edition staging criteria may not improve prognostic performance.

AB - Background: The prognostic relevance of extranodal extension (ENE) for salivary gland carcinoma (SGC) remains unclear. The present study is undertaken to investigate the predictive significance of pathological nodal parameters in surgically treated patients with nodal metastatic SGC. Methods: This multicenter cohort included 114 patients with pathologically proven node-positive SGC between 2000 and 2014. Possible correlations of clinicopathological parameters and outcomes were examined. Results: The median follow-up was 69 months (range, 11-173 months). The multivariate analysis identified metastatic node number (1-2 vs 3-6; 1-2 vs ≥7) as an independent predictor for regional control (P = 0.005; P = 0.02), locoregional control (P = 0.008; P = 0.04), distant metastasis-free survival (P = 0.17; P = 0.006), disease-free survival (P = 0.05; P = 0.002), and overall survival (P = 0.18; P = 0.009), whereas ENE was not associated with survival outcomes. Conclusions: Metastatic node number, not ENE, is an independent node-related prognosticator for SGC. Integration of ENE into the American Joint Committee on Cancer 8th edition staging criteria may not improve prognostic performance.

KW - AJCC stage

KW - N classification

KW - adjuvant radiotherapy

KW - extracapsular spread

KW - neck dissection

KW - number of positive nodes

UR - http://www.scopus.com/inward/record.url?scp=85060165263&partnerID=8YFLogxK

U2 - 10.1002/hed.25603

DO - 10.1002/hed.25603

M3 - 文章

C2 - 30652371

AN - SCOPUS:85060165263

SN - 1043-3074

VL - 41

SP - 1572

EP - 1582

JO - Head and Neck

JF - Head and Neck

IS - 6

ER -

High metastatic node number, not extranodal extension, as a node-related prognosticator in surgically treated patients with nodal metastatic salivary gland carcinoma

Abstract

Bibliographical note

Keywords

UN SDGs

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