High-throughput white blood cells (leukocytes) separation and enrichment from whole blood by hydrodynamic and inertial force

Horas Cendana Tseng, Ren Guei Wu, Hwan You Chang, Fan Gang Tseng*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

To solve clogging in microchannel and low separation rate in microfluidic devices that containing high concentration whole blood cells (4.3×10 6 cells/μl) with the remaining <1% consisting peripheral blood leukocytes and platelets [1-2]. In this work we introduce a like-biomimetic structure to separate red blood cells from whole blood and to enrich leukocytes (white blood cells) through the elastic properties of blood cell by the interaction of inertial force, shear lift, and wall crowding effect in a continuous flow system. A high separation efficiency (∼84%) and high throughput flow rate (200μl/s or 10ml/min) was obtained in this microfluidic chip.

Original languageEnglish
Title of host publication2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Pages835-838
Number of pages4
DOIs
StatePublished - 2012
Externally publishedYes
Event2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France
Duration: 29 01 201202 02 2012

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Conference

Conference2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Country/TerritoryFrance
CityParis
Period29/01/1202/02/12

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