Higher blood MLL1 mRNA and BDNF promoter IV on histone H3K4me3 levels in patients with schizophrenia

Tiao Lai Huang; Chin Chuen Lin; Rong Fu Chen; Chien Te Lee

doi:10.1016/j.psychres.2016.06.010

Higher blood MLL1 mRNA and BDNF promoter IV on histone H3K4me3 levels in patients with schizophrenia

Tiao Lai Huang^*
, Chin Chuen Lin
, Rong Fu Chen
, Chien Te Lee

^*Corresponding author for this work

School of Traditional Chinese Medicine

Chang Gung University
Show-Chwan Memorial Hospital Taiwan

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls. Over one year, 36 patients with schizophrenia and 32 controls were recruited. Psychiatric diagnoses were made based on DSM-IV criteria. Higher blood MLL1 mRNA and BDNF exon IV promoter on H3K4me3 levels were noted in patients with schizophrenia than in controls. The results showed that blood MLL1 mRNA and BDNF exon IV on H3K4me3 levels might be involved in the psychopathology of schizophrenia.

Original language	English
Pages (from-to)	207-209
Number of pages	3
Journal	Psychiatry Research
Volume	243
DOIs	https://doi.org/10.1016/j.psychres.2016.06.010
State	Published - 30 09 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ireland Ltd

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BDNF
H3K4me3
MLL1
Schizophrenia

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10.1016/j.psychres.2016.06.010

Cite this

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title = "Higher blood MLL1 mRNA and BDNF promoter IV on histone H3K4me3 levels in patients with schizophrenia",

abstract = "We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls. Over one year, 36 patients with schizophrenia and 32 controls were recruited. Psychiatric diagnoses were made based on DSM-IV criteria. Higher blood MLL1 mRNA and BDNF exon IV promoter on H3K4me3 levels were noted in patients with schizophrenia than in controls. The results showed that blood MLL1 mRNA and BDNF exon IV on H3K4me3 levels might be involved in the psychopathology of schizophrenia.",

keywords = "BDNF, H3K4me3, MLL1, Schizophrenia",

author = "Huang, \{Tiao Lai\} and Lin, \{Chin Chuen\} and Chen, \{Rong Fu\} and Lee, \{Chien Te\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd",

year = "2016",

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day = "30",

doi = "10.1016/j.psychres.2016.06.010",

language = "英语",

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T1 - Higher blood MLL1 mRNA and BDNF promoter IV on histone H3K4me3 levels in patients with schizophrenia

AU - Huang, Tiao Lai

AU - Lin, Chin Chuen

AU - Chen, Rong Fu

AU - Lee, Chien Te

PY - 2016/9/30

Y1 - 2016/9/30

N2 - We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls. Over one year, 36 patients with schizophrenia and 32 controls were recruited. Psychiatric diagnoses were made based on DSM-IV criteria. Higher blood MLL1 mRNA and BDNF exon IV promoter on H3K4me3 levels were noted in patients with schizophrenia than in controls. The results showed that blood MLL1 mRNA and BDNF exon IV on H3K4me3 levels might be involved in the psychopathology of schizophrenia.

AB - We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls. Over one year, 36 patients with schizophrenia and 32 controls were recruited. Psychiatric diagnoses were made based on DSM-IV criteria. Higher blood MLL1 mRNA and BDNF exon IV promoter on H3K4me3 levels were noted in patients with schizophrenia than in controls. The results showed that blood MLL1 mRNA and BDNF exon IV on H3K4me3 levels might be involved in the psychopathology of schizophrenia.

KW - BDNF

KW - H3K4me3

KW - MLL1

KW - Schizophrenia

UR - https://www.scopus.com/pages/publications/84978077036

U2 - 10.1016/j.psychres.2016.06.010

DO - 10.1016/j.psychres.2016.06.010

M3 - 文章

C2 - 27419650

AN - SCOPUS:84978077036

SN - 0165-1781

VL - 243

SP - 207

EP - 209

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Higher blood MLL1 mRNA and BDNF promoter IV on histone H3K4me3 levels in patients with schizophrenia

Abstract

Bibliographical note

UN SDGs

Keywords

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