Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

Koreaki Sugimoto; Koji Abe; Tsong Hai Lee; Eiko Sakurai; Kazuhiko Yanai; Kyuya Kogure; Yasuto Itoyama; Takehiko Watanabe

doi:10.1016/0006-8993(94)90784-6

Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

Koreaki Sugimoto, Koji Abe, Tsong Hai Lee, Eiko Sakurai, Kazuhiko Yanai, Kyuya Kogure, Yasuto Itoyama, Takehiko Watanabe^*

^*Corresponding author for this work

Tohoku University

Research output: Contribution to journal › Journal Article › peer-review

16 Scopus citations

Abstract

The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.

Original language	English
Pages (from-to)	279-283
Number of pages	5
Journal	Brain Research
Volume	666
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)90784-6
State	Published - 15 12 1994
Externally published	Yes

Keywords

(S)α-Fluoromethylhistidine
CA2
Gerbil
Hippocampus
Histamine
Ischemia

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10.1016/0006-8993(94)90784-6

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title = "Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons",

abstract = "The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.",

keywords = "(S)α-Fluoromethylhistidine, CA2, Gerbil, Hippocampus, Histamine, Ischemia",

author = "Koreaki Sugimoto and Koji Abe and Lee, {Tsong Hai} and Eiko Sakurai and Kazuhiko Yanai and Kyuya Kogure and Yasuto Itoyama and Takehiko Watanabe",

year = "1994",

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doi = "10.1016/0006-8993(94)90784-6",

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T1 - Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

AU - Sugimoto, Koreaki

AU - Abe, Koji

AU - Lee, Tsong Hai

AU - Sakurai, Eiko

AU - Yanai, Kazuhiko

AU - Kogure, Kyuya

AU - Itoyama, Yasuto

AU - Watanabe, Takehiko

PY - 1994/12/15

Y1 - 1994/12/15

N2 - The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.

AB - The effect of (S)α-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH. These results indicate that depletion of brain histamine aggravates neuronal death of hippocampal CA2 neurons after 3 min ischemia.

KW - (S)α-Fluoromethylhistidine

KW - CA2

KW - Gerbil

KW - Hippocampus

KW - Histamine

KW - Ischemia

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DO - 10.1016/0006-8993(94)90784-6

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AN - SCOPUS:0028152946

SN - 0006-8993

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JO - Brain Research

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ER -

Histamine depletion in brain caused by treatment with (S) α-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons

Abstract

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