Histiocytoid hemangioma of the heart with peripheral eosinophilia

Tseng‐Tong ‐T Kuo*, Swei Hsueh, Ih‐Jen ‐J Su, Jong‐Shuin ‐S Chen, Frank Gonzalez‐Crussi

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

19 Scopus citations

Abstract

A histiocytoid hemangioma of the heart is reported, which was found incidentally in a man with unusually high eosinophilia. The eosinophilia subsided dramatically following removal of the tumor. The “histiocytoid” or the “epithelioid” appearance of the tumor cells and the presence of vacuolated cells were the characteristic microscopic features. The endothelial origin of this tumor was verified by positive immunostaining for factor VIII‐related antigen and ultrastructural demonstration of intracytoplasmic lumen formation, abundant cytoplasmic filaments, pinocytotic vesicles, and prominent basal lamina. The presence of mitotic activity, cellular pleomorphism, and tumor necrosis raised the possibility of its malignant potential. The occurrence of this tumor in the heart may be mistaken for a myxoma clinically and a metastatic carcinoma pathologically.

Original languageEnglish
Pages (from-to)2854-2861
Number of pages8
JournalCancer
Volume55
Issue number12
DOIs
StatePublished - 15 06 1985
Externally publishedYes

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