Histone demethylases in prostate cancer

Ling Yu Wang; Wenchang Guo; Kevin Kim; Mamata Pochampalli; Chiu Lien Hung; Yoshihiro Izumiya; Hsing Jien Kung

doi:10.1007/978-1-4614-8039-6_15

Histone demethylases in prostate cancer

Ling Yu Wang
, Wenchang Guo
, Kevin Kim
, Mamata Pochampalli
, Chiu Lien Hung
, Yoshihiro Izumiya
, Hsing Jien Kung^*

^*Corresponding author for this work

University of California at Davis

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Accumulating evidence has suggested that epigenetic alternations are as important as genetic mutations in cancer development. It is proposed that tumors are arisen by "malignant reprogramming" driven by a combination of both genetic and epigenetic changes. It therefore comes as no surprise that histone demethylases, the newest members of the histone modifying enzymes, are found to be targets of mutations and dysregulation in cancer cells. In this review article, we provide an overview of the types of histone demethylases whose genetic structure or expression is altered in cancers, the action of histone demethylases in cancer development and their potential inhibitors. Special emphasis is placed on the roles of histone demethylases in prostate cancer progression.

Original language	English
Title of host publication	Nuclear Signaling Pathways and Targeting Transcription in Cancer
Publisher	Humana Press Inc.
Pages	373-397
Number of pages	25
ISBN (Print)	9781461480389
DOIs	https://doi.org/10.1007/978-1-4614-8039-6_15
State	Published - 2014
Externally published	Yes

Publication series

Name	Cancer Drug Discovery and Development
Volume	88
ISSN (Print)	2196-9906
ISSN (Electronic)	2196-9914

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Epigenetics
Histone demethylase
Inhibitor
Mutation
Prostate cancer

Access to Document

10.1007/978-1-4614-8039-6_15

Cite this

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AU - Wang, Ling Yu

AU - Guo, Wenchang

AU - Kim, Kevin

AU - Pochampalli, Mamata

AU - Hung, Chiu Lien

AU - Izumiya, Yoshihiro

AU - Kung, Hsing Jien

PY - 2014

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AB - Accumulating evidence has suggested that epigenetic alternations are as important as genetic mutations in cancer development. It is proposed that tumors are arisen by "malignant reprogramming" driven by a combination of both genetic and epigenetic changes. It therefore comes as no surprise that histone demethylases, the newest members of the histone modifying enzymes, are found to be targets of mutations and dysregulation in cancer cells. In this review article, we provide an overview of the types of histone demethylases whose genetic structure or expression is altered in cancers, the action of histone demethylases in cancer development and their potential inhibitors. Special emphasis is placed on the roles of histone demethylases in prostate cancer progression.

KW - Epigenetics

KW - Histone demethylase

KW - Inhibitor

KW - Mutation

KW - Prostate cancer

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M3 - 章节

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SN - 9781461480389

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BT - Nuclear Signaling Pathways and Targeting Transcription in Cancer

PB - Humana Press Inc.

ER -

Histone demethylases in prostate cancer

Abstract

Publication series

UN SDGs

Keywords

Access to Document

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