HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: An updated review

Chi Yuan Cheng, Shih Chi Su, Chi Hua Chen, Wei Li Chen, Shin Tarng Deng, Wen Hung Chung*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity. This review summarizes the literature on recent progresses in pharmacogenetic studies and clinical application of pharmacogenetic screening based on associations between SCARs and specific HLA alleles to avoid serious conditions associated with drug hypersensitivity.

Original languageEnglish
Article number565320
JournalJournal of Immunology Research
Volume2014
DOIs
StatePublished - 2014

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