HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus

Jeng Hsien Yen; Chung Jen Chen; Wen Chan Tsai; Jih Jin Tsai; Tsan Teng Ou; Hong Wen Liu

HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus

Jeng Hsien Yen, Chung Jen Chen, Wen Chan Tsai, Jih Jin Tsai, Tsan Teng Ou, Hong Wen Liu^*

^*Corresponding author for this work

Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

8 Scopus citations

Abstract

Objective. To investigate the relation of HLA-DMA and DMB alleles to the development of systemic lupus erythematosus (SLE). Methods. We studied HLA- DMA and DMB alleles in 108 patients with SLE and 138 healthy controls using the amplification created restriction site method. Results. The phenotypic frequency of HLA-DMA*0104 was significantly higher in patients with SLE than in healthy controls. The HLA-DMA and DMB alleles were not related to clinical manifestations and various laboratory tests in patients with SLE. Conclusion. HLA-DMA*0104 may be associated with the susceptibility of SLE.

Original language	English
Pages (from-to)	1930-1933
Number of pages	4
Journal	Journal of Rheumatology
Volume	26
Issue number	9
State	Published - 1999
Externally published	Yes

Keywords

HLA-DMA
HLA-DMB
MHC
Systemic lupus erythematosus

Cite this

@article{bd555f7c47664860b642ea543fff2180,

title = "HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus",

abstract = "Objective. To investigate the relation of HLA-DMA and DMB alleles to the development of systemic lupus erythematosus (SLE). Methods. We studied HLA- DMA and DMB alleles in 108 patients with SLE and 138 healthy controls using the amplification created restriction site method. Results. The phenotypic frequency of HLA-DMA*0104 was significantly higher in patients with SLE than in healthy controls. The HLA-DMA and DMB alleles were not related to clinical manifestations and various laboratory tests in patients with SLE. Conclusion. HLA-DMA*0104 may be associated with the susceptibility of SLE.",

keywords = "HLA-DMA, HLA-DMB, MHC, Systemic lupus erythematosus",

author = "Yen, {Jeng Hsien} and Chen, {Chung Jen} and Tsai, {Wen Chan} and Tsai, {Jih Jin} and Ou, {Tsan Teng} and Liu, {Hong Wen}",

year = "1999",

language = "英语",

volume = "26",

pages = "1930--1933",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology",

number = "9",

}

TY - JOUR

T1 - HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus

AU - Yen, Jeng Hsien

AU - Chen, Chung Jen

AU - Tsai, Wen Chan

AU - Tsai, Jih Jin

AU - Ou, Tsan Teng

AU - Liu, Hong Wen

PY - 1999

Y1 - 1999

N2 - Objective. To investigate the relation of HLA-DMA and DMB alleles to the development of systemic lupus erythematosus (SLE). Methods. We studied HLA- DMA and DMB alleles in 108 patients with SLE and 138 healthy controls using the amplification created restriction site method. Results. The phenotypic frequency of HLA-DMA*0104 was significantly higher in patients with SLE than in healthy controls. The HLA-DMA and DMB alleles were not related to clinical manifestations and various laboratory tests in patients with SLE. Conclusion. HLA-DMA*0104 may be associated with the susceptibility of SLE.

AB - Objective. To investigate the relation of HLA-DMA and DMB alleles to the development of systemic lupus erythematosus (SLE). Methods. We studied HLA- DMA and DMB alleles in 108 patients with SLE and 138 healthy controls using the amplification created restriction site method. Results. The phenotypic frequency of HLA-DMA*0104 was significantly higher in patients with SLE than in healthy controls. The HLA-DMA and DMB alleles were not related to clinical manifestations and various laboratory tests in patients with SLE. Conclusion. HLA-DMA*0104 may be associated with the susceptibility of SLE.

KW - HLA-DMA

KW - HLA-DMB

KW - MHC

KW - Systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=0033405161&partnerID=8YFLogxK

M3 - 文章

C2 - 10493671

AN - SCOPUS:0033405161

SN - 0315-162X

VL - 26

SP - 1930

EP - 1933

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 9

ER -

HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus

Abstract

Keywords

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