HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus

Jeng Hsien Yen, Chung Jen Chen, Wen Chan Tsai, Jih Jin Tsai, Tsan Teng Ou, Hong Wen Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations


Objective. To investigate the relation of HLA-DMA and DMB alleles to the development of systemic lupus erythematosus (SLE). Methods. We studied HLA- DMA and DMB alleles in 108 patients with SLE and 138 healthy controls using the amplification created restriction site method. Results. The phenotypic frequency of HLA-DMA*0104 was significantly higher in patients with SLE than in healthy controls. The HLA-DMA and DMB alleles were not related to clinical manifestations and various laboratory tests in patients with SLE. Conclusion. HLA-DMA*0104 may be associated with the susceptibility of SLE.

Original languageEnglish
Pages (from-to)1930-1933
Number of pages4
JournalJournal of Rheumatology
Issue number9
StatePublished - 1999
Externally publishedYes


  • MHC
  • Systemic lupus erythematosus


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