HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms

Y. J. Lin; L. Wan; J. Y. Wu; J. J.C. Sheu; C. W. Lin; Y. C. Lan; C. H. Lai; C. H. Hung; Y. Tsai; C. H. Tsai; T. H. Lin; J. G. Lin; K. C. Hsueh; Y. M. Huang; J. S. Chang; F. J. Tsai

doi:10.1002/art.24261

HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms

Y. J. Lin, L. Wan, J. Y. Wu, J. J.C. Sheu, C. W. Lin, Y. C. Lan, C. H. Lai, C. H. Hung, Y. Tsai, C. H. Tsai, T. H. Lin, J. G. Lin, K. C. Hsueh, Y. M. Huang, J. S. Chang^*, F. J. Tsai

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

61 Scopus citations

Abstract

Objective. Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown cause for which a genetic influence is supposed. The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population. Methods. The 168 genetic variants covering the MHC locus were analyzed in an association study of a Taiwanese cohort of 93 KD patients and 680 unrelated healthy children matched for sex and age with the study patients. Results. Eleven single-nucleotide polymorphisms (SNPs) were associated with the occurrence of KD. The SNP located at the 3′-untranslated region of HLA-E (rs2844724) was highly associated (P < 1 × 10^-7). In addition, the frequency of the C allele was higher in KD patients without CAAs than in controls (P < 0.001) due to a significantly increased frequency of the CC and CT genotypes. Plasma levels of soluble HLA-E were significantly higher in KD patients than in controls regardless of the presence of CAAs. Furthermore, there was a trend toward higher plasma levels of soluble HLA-E in KD patients with the CT and TT genotypes of the HLA-E gene polymorphism. Conclusion. Our results suggest that the HLA-E gene polymorphism may play a role in the pathogenesis of KD.

Original language	English
Pages (from-to)	604-610
Number of pages	7
Journal	Arthritis and Rheumatism
Volume	60
Issue number	2
DOIs	https://doi.org/10.1002/art.24261
State	Published - 02 2009
Externally published	Yes

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10.1002/art.24261

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Lin, Y. J., Wan, L., Wu, J. Y., Sheu, J. J. C., Lin, C. W., Lan, Y. C., Lai, C. H., Hung, C. H., Tsai, Y., Tsai, C. H., Lin, T. H., Lin, J. G., Hsueh, K. C., Huang, Y. M., Chang, J. S., & Tsai, F. J. (2009). HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. Arthritis and Rheumatism, 60(2), 604-610. https://doi.org/10.1002/art.24261

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title = "HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms",

abstract = "Objective. Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown cause for which a genetic influence is supposed. The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population. Methods. The 168 genetic variants covering the MHC locus were analyzed in an association study of a Taiwanese cohort of 93 KD patients and 680 unrelated healthy children matched for sex and age with the study patients. Results. Eleven single-nucleotide polymorphisms (SNPs) were associated with the occurrence of KD. The SNP located at the 3′-untranslated region of HLA-E (rs2844724) was highly associated (P < 1 × 10-7). In addition, the frequency of the C allele was higher in KD patients without CAAs than in controls (P < 0.001) due to a significantly increased frequency of the CC and CT genotypes. Plasma levels of soluble HLA-E were significantly higher in KD patients than in controls regardless of the presence of CAAs. Furthermore, there was a trend toward higher plasma levels of soluble HLA-E in KD patients with the CT and TT genotypes of the HLA-E gene polymorphism. Conclusion. Our results suggest that the HLA-E gene polymorphism may play a role in the pathogenesis of KD.",

author = "Lin, {Y. J.} and L. Wan and Wu, {J. Y.} and Sheu, {J. J.C.} and Lin, {C. W.} and Lan, {Y. C.} and Lai, {C. H.} and Hung, {C. H.} and Y. Tsai and Tsai, {C. H.} and Lin, {T. H.} and Lin, {J. G.} and Hsueh, {K. C.} and Huang, {Y. M.} and Chang, {J. S.} and Tsai, {F. J.}",

year = "2009",

month = feb,

doi = "10.1002/art.24261",

language = "英语",

volume = "60",

pages = "604--610",

journal = "Arthritis and Rheumatism",

issn = "0004-3591",

publisher = "John Wiley & Sons Inc.",

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T1 - HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms

AU - Lin, Y. J.

AU - Wan, L.

AU - Wu, J. Y.

AU - Sheu, J. J.C.

AU - Lin, C. W.

AU - Lan, Y. C.

AU - Lai, C. H.

AU - Hung, C. H.

AU - Tsai, Y.

AU - Tsai, C. H.

AU - Lin, T. H.

AU - Lin, J. G.

AU - Hsueh, K. C.

AU - Huang, Y. M.

AU - Chang, J. S.

AU - Tsai, F. J.

PY - 2009/2

Y1 - 2009/2

N2 - Objective. Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown cause for which a genetic influence is supposed. The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population. Methods. The 168 genetic variants covering the MHC locus were analyzed in an association study of a Taiwanese cohort of 93 KD patients and 680 unrelated healthy children matched for sex and age with the study patients. Results. Eleven single-nucleotide polymorphisms (SNPs) were associated with the occurrence of KD. The SNP located at the 3′-untranslated region of HLA-E (rs2844724) was highly associated (P < 1 × 10-7). In addition, the frequency of the C allele was higher in KD patients without CAAs than in controls (P < 0.001) due to a significantly increased frequency of the CC and CT genotypes. Plasma levels of soluble HLA-E were significantly higher in KD patients than in controls regardless of the presence of CAAs. Furthermore, there was a trend toward higher plasma levels of soluble HLA-E in KD patients with the CT and TT genotypes of the HLA-E gene polymorphism. Conclusion. Our results suggest that the HLA-E gene polymorphism may play a role in the pathogenesis of KD.

AB - Objective. Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown cause for which a genetic influence is supposed. The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population. Methods. The 168 genetic variants covering the MHC locus were analyzed in an association study of a Taiwanese cohort of 93 KD patients and 680 unrelated healthy children matched for sex and age with the study patients. Results. Eleven single-nucleotide polymorphisms (SNPs) were associated with the occurrence of KD. The SNP located at the 3′-untranslated region of HLA-E (rs2844724) was highly associated (P < 1 × 10-7). In addition, the frequency of the C allele was higher in KD patients without CAAs than in controls (P < 0.001) due to a significantly increased frequency of the CC and CT genotypes. Plasma levels of soluble HLA-E were significantly higher in KD patients than in controls regardless of the presence of CAAs. Furthermore, there was a trend toward higher plasma levels of soluble HLA-E in KD patients with the CT and TT genotypes of the HLA-E gene polymorphism. Conclusion. Our results suggest that the HLA-E gene polymorphism may play a role in the pathogenesis of KD.

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U2 - 10.1002/art.24261

DO - 10.1002/art.24261

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SN - 0004-3591

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EP - 610

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

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ER -

HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms

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