Homocysteine and C-reactive protein as useful surrogate markers for evaluating CKD risk in adults

Chung Hsun Chuang, Yi Yen Lee, Bor Fuh Sheu, Cheng Ting Hsiao, Song Seng Loke, Jih Chang Chen, Wen Cheng Li*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

16 Scopus citations


Background/Aims: This study aimed to evaluate the effectiveness of homocysteine and C-reactive protein (CRP) as potential markers for chronic kidney disease (CKD) in adults in Taiwan, and to identify associations between these factors and CKD, stratifying by gender. Methods: This cross-sectional study analyzed multi-center data retrospectively. Data were collected from 22,043 adult Taiwanese at Chang-Gung Memorial Hospital from 2005 to 2011. Smoking/drinking history, personal medical/medication history, pregnancy, fasting times as well as laboratory parameters, including homocysteine and CRP were measured and analyzed. Results: Significant differences were observed between four homocysteine and CRP quartiles in eGFR and CKD. For males, only one model showed significant associations between plasma homocysteine and CKD, while in females, all three models showed significant associations with CKD. On the contrary, the gender difference in the case of CRP was opposite. Combined homocysteine and CRP were associated with CKD in males but not in females. Conclusion: Among Taiwanese adults, plasma homocysteine is associated with CKD in females and plasma hsCRP is associated with CKD in males. High hsCRP/high homocysteine is associated with elevated CKD risk in male. Our results suggest that homocysteine and hsCRP may be useful surrogate markers for evaluating CKD risk in adults.

Original languageEnglish
Pages (from-to)402-413
Number of pages12
JournalKidney and Blood Pressure Research
Issue number4-5
StatePublished - 2013
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2013 S. Karger AG, Basel.


  • C-reactive protein
  • Chronic kidney disease
  • Homocysteine
  • Risk


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