How lymphocytes kill

Lucy H.Y. Young; Chau Ching Liu; Sanjay Joag; Shahin Rafii; John Ding E. Young

doi:10.1146/annurev.me.41.020190.000401

How lymphocytes kill

Lucy H.Y. Young^*
, Chau Ching Liu
, Sanjay Joag
, Shahin Rafii
, John Ding E. Young

^*Corresponding author for this work

Harvard University
Rockefeller University

Research output: Contribution to journal › Journal Article › peer-review

24 Scopus citations

Abstract

Cytotoxic T lymphocytes and natural killer cells are potent killers of target cells. These lymphocytes have large cytoplasmic granules containing cytotoxic peptides and other factors. Several of these molecules have been isolated and their functions elucidated. These molecules may be directly involved in the killing of virus-infected and transformed cells as well as in the development of cell-mediated autoimmune disorders.

Original language	English
Pages (from-to)	45-54
Number of pages	10
Journal	Annual Review of Medicine
Volume	41
Issue number	1
DOIs	https://doi.org/10.1146/annurev.me.41.020190.000401
State	Published - 1990
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Autoimmune diseases
Cell-mediated killing
Cytotoxicity
Perform
Pore-forming protein
Viral infections

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10.1146/annurev.me.41.020190.000401

Cite this

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title = "How lymphocytes kill",

abstract = "Cytotoxic T lymphocytes and natural killer cells are potent killers of target cells. These lymphocytes have large cytoplasmic granules containing cytotoxic peptides and other factors. Several of these molecules have been isolated and their functions elucidated. These molecules may be directly involved in the killing of virus-infected and transformed cells as well as in the development of cell-mediated autoimmune disorders.",

keywords = "Autoimmune diseases, Cell-mediated killing, Cytotoxicity, Perform, Pore-forming protein, Viral infections",

author = "Young, \{Lucy H.Y.\} and Liu, \{Chau Ching\} and Sanjay Joag and Shahin Rafii and Young, \{John Ding E.\}",

year = "1990",

doi = "10.1146/annurev.me.41.020190.000401",

language = "英语",

volume = "41",

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T1 - How lymphocytes kill

AU - Young, Lucy H.Y.

AU - Liu, Chau Ching

AU - Joag, Sanjay

AU - Rafii, Shahin

AU - Young, John Ding E.

PY - 1990

Y1 - 1990

N2 - Cytotoxic T lymphocytes and natural killer cells are potent killers of target cells. These lymphocytes have large cytoplasmic granules containing cytotoxic peptides and other factors. Several of these molecules have been isolated and their functions elucidated. These molecules may be directly involved in the killing of virus-infected and transformed cells as well as in the development of cell-mediated autoimmune disorders.

AB - Cytotoxic T lymphocytes and natural killer cells are potent killers of target cells. These lymphocytes have large cytoplasmic granules containing cytotoxic peptides and other factors. Several of these molecules have been isolated and their functions elucidated. These molecules may be directly involved in the killing of virus-infected and transformed cells as well as in the development of cell-mediated autoimmune disorders.

KW - Autoimmune diseases

KW - Cell-mediated killing

KW - Cytotoxicity

KW - Perform

KW - Pore-forming protein

KW - Viral infections

UR - https://www.scopus.com/pages/publications/0025268392

U2 - 10.1146/annurev.me.41.020190.000401

DO - 10.1146/annurev.me.41.020190.000401

M3 - 文章

C2 - 2184743

AN - SCOPUS:0025268392

SN - 0066-4219

VL - 41

SP - 45

EP - 54

JO - Annual Review of Medicine

JF - Annual Review of Medicine

IS - 1

ER -

How lymphocytes kill

Abstract

UN SDGs

Keywords

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