TY - JOUR
T1 - Human blood test based on surface-enhanced Raman spectroscopy technology using different excitation light for nasopharyngeal cancer detection
AU - Lin, Huijing
AU - Zhou, Jiahui
AU - Wu, Qiong
AU - Hung, Tsung Min
AU - Chen, Weiwei
AU - Yu, Yun
AU - Chang, Joseph Tung Chieh
AU - Pan, Jianji
AU - Qiu, Sufang
AU - Chen, Rong
N1 - Publisher Copyright:
© 2019 Institution of Engineering and Technology. All rights reserved.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Nasopharyngeal carcinoma (NPC), a kind of squamous cell carcinoma, occurs in the top and the side wall of nasopharyngeal, which harms human health and life. In this study, a novel blood test (SERS) was carried out for 30 NPC patients and 30 normal ones. Using multi-variate statistical analysis for spectral data, the diagnostic sensitivities of 89.3% (50/56) and 85.7% (48/56) can be achieved for 633 and 785 nm exciting wavelength, respectively. Also corresponding specificities are 71.4% (41/56) and 78.6% (44/56), respectively. These results demonstrated that the two kinds of excitation wavelength all have the feasibility of obtaining high-quality SERS spectra to differentiate cancer from normal samples. Furthermore, the performance of the SERS test with 785 nm wavelength excitation is nearly equal to the SERS experimental effect under 633 nm wavelength excitation for NPC detection.
AB - Nasopharyngeal carcinoma (NPC), a kind of squamous cell carcinoma, occurs in the top and the side wall of nasopharyngeal, which harms human health and life. In this study, a novel blood test (SERS) was carried out for 30 NPC patients and 30 normal ones. Using multi-variate statistical analysis for spectral data, the diagnostic sensitivities of 89.3% (50/56) and 85.7% (48/56) can be achieved for 633 and 785 nm exciting wavelength, respectively. Also corresponding specificities are 71.4% (41/56) and 78.6% (44/56), respectively. These results demonstrated that the two kinds of excitation wavelength all have the feasibility of obtaining high-quality SERS spectra to differentiate cancer from normal samples. Furthermore, the performance of the SERS test with 785 nm wavelength excitation is nearly equal to the SERS experimental effect under 633 nm wavelength excitation for NPC detection.
UR - http://www.scopus.com/inward/record.url?scp=85076136536&partnerID=8YFLogxK
U2 - 10.1049/iet-nbt.2019.0221
DO - 10.1049/iet-nbt.2019.0221
M3 - 文章
C2 - 31811763
AN - SCOPUS:85076136536
SN - 1751-8741
VL - 13
SP - 942
EP - 945
JO - IET Nanobiotechnology
JF - IET Nanobiotechnology
IS - 9
ER -
