TY - JOUR
T1 - Human papillomavirus infection and papillary squamous cell carcinoma in the head and neck region
AU - Yang, Chao-Hui
AU - Huang, Chao Cheng
AU - Ko, Ming Tse
AU - Wei, Yu Ching
AU - Hwang, Chung-Feng
PY - 2013/2
Y1 - 2013/2
N2 - Papillary squamous cell carcinoma (PSCC) is a rare variant of SCC in the head and neck region. The role of human papillomavirus (HPV) infection in PSCC is still unclear. We retrospectively reviewed 11 PSCCs in our institute over a 21-year period and compared the HPV status of PSCCs with 26 squamous cell papillomas (SCPs). Polymerase chain reaction (PCR) amplification to detect HPV DNA and in situ hybridization (ISH) were performed to analyze the relationship between the papillary lesions and HPV infection. Immunohistochemical (IHC) staining for p16 protein expression was used to analyze the PSCC specimens. Nine of 11 (82 %), eight of 11 (73 %), and eight of 11 (73 %) PSCC samples were found to be HPV positive by PCR, ISH, and IHC staining for p16 protein expression, respectively. PSCC had a significantly higher rate of HPV infection than SCP by PCR (p = 0.002) and ISH (p = 0.001) analysis. This study presents different HPV status in two papillary neoplasms and may help to clarify the unique morphological and biological characteristics of head and neck PSCC.
AB - Papillary squamous cell carcinoma (PSCC) is a rare variant of SCC in the head and neck region. The role of human papillomavirus (HPV) infection in PSCC is still unclear. We retrospectively reviewed 11 PSCCs in our institute over a 21-year period and compared the HPV status of PSCCs with 26 squamous cell papillomas (SCPs). Polymerase chain reaction (PCR) amplification to detect HPV DNA and in situ hybridization (ISH) were performed to analyze the relationship between the papillary lesions and HPV infection. Immunohistochemical (IHC) staining for p16 protein expression was used to analyze the PSCC specimens. Nine of 11 (82 %), eight of 11 (73 %), and eight of 11 (73 %) PSCC samples were found to be HPV positive by PCR, ISH, and IHC staining for p16 protein expression, respectively. PSCC had a significantly higher rate of HPV infection than SCP by PCR (p = 0.002) and ISH (p = 0.001) analysis. This study presents different HPV status in two papillary neoplasms and may help to clarify the unique morphological and biological characteristics of head and neck PSCC.
KW - HNSCC
KW - Human papillomavirus
KW - Papillary squamous cell carcinoma
KW - Squamous cell papilloma
KW - p16
UR - https://www.scopus.com/pages/publications/84872769433
U2 - 10.1007/s13277-012-0551-8
DO - 10.1007/s13277-012-0551-8
M3 - 文献综述
C2 - 23065573
AN - SCOPUS:84872769433
SN - 1423-0380
VL - 34
SP - 301
EP - 307
JO - Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
JF - Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
IS - 1
ER -
