Human papillomaviruses and small cell carcinoma of the uterine cervix

Chia C. Pao*, Chieh Yu Lin, Ya Li Chang, Chih Jen Tseng, Swei Hsueh

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

33 Scopus citations

Abstract

The in vitro DNA amplification technique of polymerase chain reaction was used to evaluate the possible presence of human papillomavirus (HPV) in small cell carcinoma of the uterine cervix. None of the 12 cases examined contain detectable amounts of either HPV type 16, 18, 31, or 33 DNA. On the other hand, HPV types 16 and 18 DNA were found in 14 (93.3%) and 9 (60.0%) of 25 invasive cervical squamous carcinoma tissues. The results seem to suggest that these types of HPV are not present or are present in extremely small quantities in cervical small cell carcinoma. Such an absence of HPV DNA makes it unlikely that these types of HPV play any etiological role in the pathogenesis of cervical small cell carcinoma.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalGynecologic Oncology
Volume43
Issue number3
DOIs
StatePublished - 12 1991

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