Human poisoning with glyphosate-surfactant herbicides: Retrospective analysis of mortality outcomes of patients treated in a poison center

Kuan Hung Liu; Shu Sen Chang; Chao Ying Tu; Hsien Yi Chen; Wen Chin Lee; Kai Fan Tsai; Po Yen Kuo; Ju Ching Yen; I. Kuan Wang; Tzung Hai Yen

doi:10.1177/09603271241297004

Human poisoning with glyphosate-surfactant herbicides: Retrospective analysis of mortality outcomes of patients treated in a poison center

Kuan Hung Liu
, Shu Sen Chang
, Chao Ying Tu
, Hsien Yi Chen
, Wen Chin Lee
, Kai Fan Tsai
, Po Yen Kuo
, Ju Ching Yen
, I. Kuan Wang
, Tzung Hai Yen^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

INTRODUCTION: The toxicity and carcinogenicity of glyphosate have long been debated. Nevertheless, the mortality rate in patients with acute glyphosate-surfactant poisoning varies across different groups.

METHODS: Between 2002 and 2020, 109 patients with glyphosate-surfactant poisoning received treatment at Chang Gung Memorial Hospital. Patients were stratified into two subgroups according to their prognosis: good ( n = 74) or poor ( n = 35). Baseline demographics, psychiatric comorbidities, medical complications, and laboratory data were collected, and mortality data were analyzed.

RESULTS: The patients were 54.1 ± 17.5 years of age and were mostly male (68.8%). Most patients (91.7%) ingested pesticides intentionally, and patients arrived at the hospital within 7.1 ± 12.7 h. Psychiatric comorbidities were prevalent, and the top three comorbidities were mental (71.6%), depressive (48.6%), and adjustment (14.7%) disorder. Patients with poor prognoses were older than those with good prognoses ( p = .007). Moreover, patients with poor prognoses had lower Glasgow Coma Scale scores ( p < .001) and diastolic blood pressure ( p = .008), but higher incidences of upper gastrointestinal bleeding ( p < .001), aspiration pneumonia ( p < .001), hypotension ( p < .001), hyperglycemia ( p = .002), acute kidney injury ( p < .001), and metabolic acidosis ( p < .001) than patients with good prognoses. The mortality rate was 5.5%. A multivariate-logistic-regression model revealed that the Glasgow Coma Scale score was a significant risk factor for poor prognosis (odds ratio 0.653, confidence interval 0.427-0.998; p = .049). However, no risk factors for mortality were identified.

CONCLUSIONS: A total of 32.1% of patients with glyphosate-surfactant poisoning had poor prognoses, and 5.5% of patients died despite treatment. The mortality outcome is comparable to that of published reports from other international poison centers.

Original language	English
Journal	Human and Experimental Toxicology
Volume	43
DOIs	https://doi.org/10.1177/09603271241297004
State	Published - 01 01 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

Keywords

Glyphosate-surfactant
mortality
pesticide
poisoning
psychiatric comorbidity
suicide
Prognosis
Humans
Middle Aged
Male
Glyphosate
Herbicides/poisoning
Poison Control Centers/statistics & numerical data
Female
Adult
Glycine/analogs & derivatives
Retrospective Studies
Aged
Surface-Active Agents/poisoning

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/09603271241297004

Cite this

@article{580974d00e5f4600a8889436b4079d9f,

title = "Human poisoning with glyphosate-surfactant herbicides: Retrospective analysis of mortality outcomes of patients treated in a poison center",

abstract = "INTRODUCTION: The toxicity and carcinogenicity of glyphosate have long been debated. Nevertheless, the mortality rate in patients with acute glyphosate-surfactant poisoning varies across different groups.METHODS: Between 2002 and 2020, 109 patients with glyphosate-surfactant poisoning received treatment at Chang Gung Memorial Hospital. Patients were stratified into two subgroups according to their prognosis: good ( n = 74) or poor ( n = 35). Baseline demographics, psychiatric comorbidities, medical complications, and laboratory data were collected, and mortality data were analyzed. RESULTS: The patients were 54.1 ± 17.5 years of age and were mostly male (68.8\%). Most patients (91.7\%) ingested pesticides intentionally, and patients arrived at the hospital within 7.1 ± 12.7 h. Psychiatric comorbidities were prevalent, and the top three comorbidities were mental (71.6\%), depressive (48.6\%), and adjustment (14.7\%) disorder. Patients with poor prognoses were older than those with good prognoses ( p = .007). Moreover, patients with poor prognoses had lower Glasgow Coma Scale scores ( p < .001) and diastolic blood pressure ( p = .008), but higher incidences of upper gastrointestinal bleeding ( p < .001), aspiration pneumonia ( p < .001), hypotension ( p < .001), hyperglycemia ( p = .002), acute kidney injury ( p < .001), and metabolic acidosis ( p < .001) than patients with good prognoses. The mortality rate was 5.5\%. A multivariate-logistic-regression model revealed that the Glasgow Coma Scale score was a significant risk factor for poor prognosis (odds ratio 0.653, confidence interval 0.427-0.998; p = .049). However, no risk factors for mortality were identified. CONCLUSIONS: A total of 32.1\% of patients with glyphosate-surfactant poisoning had poor prognoses, and 5.5\% of patients died despite treatment. The mortality outcome is comparable to that of published reports from other international poison centers.",

keywords = "Glyphosate-surfactant, mortality, pesticide, poisoning, psychiatric comorbidity, suicide, Prognosis, Humans, Middle Aged, Male, Glyphosate, Herbicides/poisoning, Poison Control Centers/statistics \& numerical data, Female, Adult, Glycine/analogs \& derivatives, Retrospective Studies, Aged, Surface-Active Agents/poisoning",

author = "Liu, \{Kuan Hung\} and Chang, \{Shu Sen\} and Tu, \{Chao Ying\} and Chen, \{Hsien Yi\} and Lee, \{Wen Chin\} and Tsai, \{Kai Fan\} and Kuo, \{Po Yen\} and Yen, \{Ju Ching\} and Wang, \{I. Kuan\} and Yen, \{Tzung Hai\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = jan,

day = "1",

doi = "10.1177/09603271241297004",

language = "英语",

volume = "43",

journal = "Human and Experimental Toxicology",

issn = "0960-3271",

publisher = "SAGE Publications Inc.",

}

TY - JOUR

T1 - Human poisoning with glyphosate-surfactant herbicides

T2 - Retrospective analysis of mortality outcomes of patients treated in a poison center

AU - Liu, Kuan Hung

AU - Chang, Shu Sen

AU - Tu, Chao Ying

AU - Chen, Hsien Yi

AU - Lee, Wen Chin

AU - Tsai, Kai Fan

AU - Kuo, Po Yen

AU - Yen, Ju Ching

AU - Wang, I. Kuan

AU - Yen, Tzung Hai

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/1/1

Y1 - 2024/1/1

N2 - INTRODUCTION: The toxicity and carcinogenicity of glyphosate have long been debated. Nevertheless, the mortality rate in patients with acute glyphosate-surfactant poisoning varies across different groups.METHODS: Between 2002 and 2020, 109 patients with glyphosate-surfactant poisoning received treatment at Chang Gung Memorial Hospital. Patients were stratified into two subgroups according to their prognosis: good ( n = 74) or poor ( n = 35). Baseline demographics, psychiatric comorbidities, medical complications, and laboratory data were collected, and mortality data were analyzed. RESULTS: The patients were 54.1 ± 17.5 years of age and were mostly male (68.8%). Most patients (91.7%) ingested pesticides intentionally, and patients arrived at the hospital within 7.1 ± 12.7 h. Psychiatric comorbidities were prevalent, and the top three comorbidities were mental (71.6%), depressive (48.6%), and adjustment (14.7%) disorder. Patients with poor prognoses were older than those with good prognoses ( p = .007). Moreover, patients with poor prognoses had lower Glasgow Coma Scale scores ( p < .001) and diastolic blood pressure ( p = .008), but higher incidences of upper gastrointestinal bleeding ( p < .001), aspiration pneumonia ( p < .001), hypotension ( p < .001), hyperglycemia ( p = .002), acute kidney injury ( p < .001), and metabolic acidosis ( p < .001) than patients with good prognoses. The mortality rate was 5.5%. A multivariate-logistic-regression model revealed that the Glasgow Coma Scale score was a significant risk factor for poor prognosis (odds ratio 0.653, confidence interval 0.427-0.998; p = .049). However, no risk factors for mortality were identified. CONCLUSIONS: A total of 32.1% of patients with glyphosate-surfactant poisoning had poor prognoses, and 5.5% of patients died despite treatment. The mortality outcome is comparable to that of published reports from other international poison centers.

AB - INTRODUCTION: The toxicity and carcinogenicity of glyphosate have long been debated. Nevertheless, the mortality rate in patients with acute glyphosate-surfactant poisoning varies across different groups.METHODS: Between 2002 and 2020, 109 patients with glyphosate-surfactant poisoning received treatment at Chang Gung Memorial Hospital. Patients were stratified into two subgroups according to their prognosis: good ( n = 74) or poor ( n = 35). Baseline demographics, psychiatric comorbidities, medical complications, and laboratory data were collected, and mortality data were analyzed. RESULTS: The patients were 54.1 ± 17.5 years of age and were mostly male (68.8%). Most patients (91.7%) ingested pesticides intentionally, and patients arrived at the hospital within 7.1 ± 12.7 h. Psychiatric comorbidities were prevalent, and the top three comorbidities were mental (71.6%), depressive (48.6%), and adjustment (14.7%) disorder. Patients with poor prognoses were older than those with good prognoses ( p = .007). Moreover, patients with poor prognoses had lower Glasgow Coma Scale scores ( p < .001) and diastolic blood pressure ( p = .008), but higher incidences of upper gastrointestinal bleeding ( p < .001), aspiration pneumonia ( p < .001), hypotension ( p < .001), hyperglycemia ( p = .002), acute kidney injury ( p < .001), and metabolic acidosis ( p < .001) than patients with good prognoses. The mortality rate was 5.5%. A multivariate-logistic-regression model revealed that the Glasgow Coma Scale score was a significant risk factor for poor prognosis (odds ratio 0.653, confidence interval 0.427-0.998; p = .049). However, no risk factors for mortality were identified. CONCLUSIONS: A total of 32.1% of patients with glyphosate-surfactant poisoning had poor prognoses, and 5.5% of patients died despite treatment. The mortality outcome is comparable to that of published reports from other international poison centers.

KW - Glyphosate-surfactant

KW - mortality

KW - pesticide

KW - poisoning

KW - psychiatric comorbidity

KW - suicide

KW - Prognosis

KW - Humans

KW - Middle Aged

KW - Male

KW - Glyphosate

KW - Herbicides/poisoning

KW - Poison Control Centers/statistics & numerical data

KW - Female

KW - Adult

KW - Glycine/analogs & derivatives

KW - Retrospective Studies

KW - Aged

KW - Surface-Active Agents/poisoning

UR - https://www.scopus.com/pages/publications/85207159824

U2 - 10.1177/09603271241297004

DO - 10.1177/09603271241297004

M3 - 文章

C2 - 39439199

AN - SCOPUS:85207159824

SN - 0960-3271

VL - 43

JO - Human and Experimental Toxicology

JF - Human and Experimental Toxicology

ER -

Human poisoning with glyphosate-surfactant herbicides: Retrospective analysis of mortality outcomes of patients treated in a poison center

Abstract

Bibliographical note

Keywords

UN SDGs

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