Hyaluronan-cisplatin conjugate nanoparticles embedded in eudragit S100-coated pectin/alginate microbeads for colon drug delivery

Shiao Wen Tsai, Ding Syuan Yu, Shu Wei Tsao, Fu Yin Hsu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

36 Scopus citations

Abstract

Hyaluronan-cisplatin conjugate nanoparticles (HCNPs) were chosen as colon-targeting drug-delivery carriers due to the observation that a variety of malignant tumors overexpress hyaluronan receptors. HCNPs were prepared by mixing cisplatin with a hyaluronan solution, followed by dialysis to remove trace elements. The cells treated with HCNPs showed significantly lower viability than those treated with cisplatin alone. HCNPs were entrapped in Eudragit S100-coated pectinate/alginate microbeads (PAMs) by using an electrospray method and a polyelectrolyte multilayer-coating technique in aqueous solution. The release profile of HCNPs from Eudragit S100-coated HCNP-PAMs was pH-dependent. The percentage of 24-hour drug release was approximately 25.1% and 39.7% in pH 1.2 and pH 4.5 media, respectively. However, the percentage of drug released quickly rose to 75.6% at pH 7.4. Moreover, the result of an in vivo nephrotoxicity study demonstrated that Eudragit S100-coated HCNP-PAMs treatment could mitigate the nephrotoxicity that resulted from cisplatin. From these results, it can be concluded that Eudragit S100-coated HCNP-PAMs are promising carriers for colon- specific drug delivery.

Original languageEnglish
Pages (from-to)2399-2407
Number of pages9
JournalInternational Journal of Nanomedicine
Volume8
DOIs
StatePublished - 2013

Keywords

  • Alginate
  • Cisplatin
  • Drug delivery
  • Hyaluronan
  • Pectin
  • Ph-dependent

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