Hybrid Core-Shell Nanofibrous Scaffolds/Stents Deliver Angiotensin II Receptor Blocker to Treat Diabetic Artery Disease

Chen Hung Lee; Ming Jer Hsieh; Julien George Roth; Xuebin Fu; Chen Hui Lu; Kuo Chun Hung; Chi Ching Kuo; Shih Jung Liu

doi:10.1021/acsapm.2c00186

Hybrid Core-Shell Nanofibrous Scaffolds/Stents Deliver Angiotensin II Receptor Blocker to Treat Diabetic Artery Disease

Chen Hung Lee^*, Ming Jer Hsieh, Julien George Roth, Xuebin Fu, Chen Hui Lu, Kuo Chun Hung, Chi Ching Kuo^*, Shih Jung Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

8 Scopus citations

Abstract

Most patients with diabetes suffer from impaired endothelial function and neointimal thickening, which contribute to arterial atherosclerosis and increase the frequency of adverse cardiovascular events. Angiotensin II receptor blockers (BIBR-277; telmisartan) exhibit distinct peroxisome proliferator-activated receptor-γ activation, which is beneficial in the treatment of arterial diseases and atherosclerosis. This investigation proposes the use of biodegradable core-shell nanofibers for the sustained and local delivery of BIBR-277 to the wall of a balloon-injured artery in the abdominal aorta of diabetic rabbits. Poly(D,L)-lactide-co-glycolide (50:50) and solutions of BIBR-277 or Dulbecco’s phosphate-buffered saline were electrospun as nanofibrous tubes and subsequently mounted on bare-metal stents. These biodegradable nanofibers released BIBR-277 for 28 days without any observable burst effect. Moreover, the drug-loaded nanofibers sustained the local delivery of BIBR-277 and increased the migration of endothelial progenitor cells in vitro while both promoting reendothelialization and decreasing the proliferation of smooth muscle cells in vivo. In conclusion, herein, a core-shell scaffold that incorporates BIBR-277-loaded nanofibers is demonstrated to sustainably deliver cardiovascular drugs and, in doing so, provides an insight into the management of the accelerated atherosclerotic vascular disease in patients with diabetes.

Original language	English
Pages (from-to)	4199-4207
Number of pages	9
Journal	ACS Applied Polymer Materials
Volume	4
Issue number	6
DOIs	https://doi.org/10.1021/acsapm.2c00186
State	Published - 10 06 2022

Bibliographical note

Publisher Copyright:
© 2022 American Chemical Society.

Keywords

BIBR-277
co-axial electrospinning
core-shell nanofiber
diabetes
re-endothelialization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsapm.2c00186

Cite this

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title = "Hybrid Core-Shell Nanofibrous Scaffolds/Stents Deliver Angiotensin II Receptor Blocker to Treat Diabetic Artery Disease",

abstract = "Most patients with diabetes suffer from impaired endothelial function and neointimal thickening, which contribute to arterial atherosclerosis and increase the frequency of adverse cardiovascular events. Angiotensin II receptor blockers (BIBR-277; telmisartan) exhibit distinct peroxisome proliferator-activated receptor-γ activation, which is beneficial in the treatment of arterial diseases and atherosclerosis. This investigation proposes the use of biodegradable core-shell nanofibers for the sustained and local delivery of BIBR-277 to the wall of a balloon-injured artery in the abdominal aorta of diabetic rabbits. Poly(D,L)-lactide-co-glycolide (50:50) and solutions of BIBR-277 or Dulbecco{\textquoteright}s phosphate-buffered saline were electrospun as nanofibrous tubes and subsequently mounted on bare-metal stents. These biodegradable nanofibers released BIBR-277 for 28 days without any observable burst effect. Moreover, the drug-loaded nanofibers sustained the local delivery of BIBR-277 and increased the migration of endothelial progenitor cells in vitro while both promoting reendothelialization and decreasing the proliferation of smooth muscle cells in vivo. In conclusion, herein, a core-shell scaffold that incorporates BIBR-277-loaded nanofibers is demonstrated to sustainably deliver cardiovascular drugs and, in doing so, provides an insight into the management of the accelerated atherosclerotic vascular disease in patients with diabetes.",

keywords = "BIBR-277, co-axial electrospinning, core-shell nanofiber, diabetes, re-endothelialization",

author = "Lee, \{Chen Hung\} and Hsieh, \{Ming Jer\} and Roth, \{Julien George\} and Xuebin Fu and Lu, \{Chen Hui\} and Hung, \{Kuo Chun\} and Kuo, \{Chi Ching\} and Liu, \{Shih Jung\}",

note = "Publisher Copyright: {\textcopyright} 2022 American Chemical Society.",

year = "2022",

month = jun,

day = "10",

doi = "10.1021/acsapm.2c00186",

language = "英语",

volume = "4",

pages = "4199--4207",

journal = "ACS Applied Polymer Materials",

issn = "2637-6105",

publisher = "American Chemical Society",

number = "6",

}

TY - JOUR

T1 - Hybrid Core-Shell Nanofibrous Scaffolds/Stents Deliver Angiotensin II Receptor Blocker to Treat Diabetic Artery Disease

AU - Lee, Chen Hung

AU - Hsieh, Ming Jer

AU - Roth, Julien George

AU - Fu, Xuebin

AU - Lu, Chen Hui

AU - Hung, Kuo Chun

AU - Kuo, Chi Ching

AU - Liu, Shih Jung

PY - 2022/6/10

Y1 - 2022/6/10

N2 - Most patients with diabetes suffer from impaired endothelial function and neointimal thickening, which contribute to arterial atherosclerosis and increase the frequency of adverse cardiovascular events. Angiotensin II receptor blockers (BIBR-277; telmisartan) exhibit distinct peroxisome proliferator-activated receptor-γ activation, which is beneficial in the treatment of arterial diseases and atherosclerosis. This investigation proposes the use of biodegradable core-shell nanofibers for the sustained and local delivery of BIBR-277 to the wall of a balloon-injured artery in the abdominal aorta of diabetic rabbits. Poly(D,L)-lactide-co-glycolide (50:50) and solutions of BIBR-277 or Dulbecco’s phosphate-buffered saline were electrospun as nanofibrous tubes and subsequently mounted on bare-metal stents. These biodegradable nanofibers released BIBR-277 for 28 days without any observable burst effect. Moreover, the drug-loaded nanofibers sustained the local delivery of BIBR-277 and increased the migration of endothelial progenitor cells in vitro while both promoting reendothelialization and decreasing the proliferation of smooth muscle cells in vivo. In conclusion, herein, a core-shell scaffold that incorporates BIBR-277-loaded nanofibers is demonstrated to sustainably deliver cardiovascular drugs and, in doing so, provides an insight into the management of the accelerated atherosclerotic vascular disease in patients with diabetes.

AB - Most patients with diabetes suffer from impaired endothelial function and neointimal thickening, which contribute to arterial atherosclerosis and increase the frequency of adverse cardiovascular events. Angiotensin II receptor blockers (BIBR-277; telmisartan) exhibit distinct peroxisome proliferator-activated receptor-γ activation, which is beneficial in the treatment of arterial diseases and atherosclerosis. This investigation proposes the use of biodegradable core-shell nanofibers for the sustained and local delivery of BIBR-277 to the wall of a balloon-injured artery in the abdominal aorta of diabetic rabbits. Poly(D,L)-lactide-co-glycolide (50:50) and solutions of BIBR-277 or Dulbecco’s phosphate-buffered saline were electrospun as nanofibrous tubes and subsequently mounted on bare-metal stents. These biodegradable nanofibers released BIBR-277 for 28 days without any observable burst effect. Moreover, the drug-loaded nanofibers sustained the local delivery of BIBR-277 and increased the migration of endothelial progenitor cells in vitro while both promoting reendothelialization and decreasing the proliferation of smooth muscle cells in vivo. In conclusion, herein, a core-shell scaffold that incorporates BIBR-277-loaded nanofibers is demonstrated to sustainably deliver cardiovascular drugs and, in doing so, provides an insight into the management of the accelerated atherosclerotic vascular disease in patients with diabetes.

KW - BIBR-277

KW - co-axial electrospinning

KW - core-shell nanofiber

KW - diabetes

KW - re-endothelialization

UR - https://www.scopus.com/pages/publications/85137121659

U2 - 10.1021/acsapm.2c00186

DO - 10.1021/acsapm.2c00186

M3 - 文章

SN - 2637-6105

VL - 4

SP - 4199

EP - 4207

JO - ACS Applied Polymer Materials

JF - ACS Applied Polymer Materials

IS - 6

ER -

Hybrid Core-Shell Nanofibrous Scaffolds/Stents Deliver Angiotensin II Receptor Blocker to Treat Diabetic Artery Disease

Abstract

Bibliographical note

Keywords

UN SDGs

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