Hydroperoxysterols from the tunicate Eudistoma sp.

Ping Jyun Sung; Mei Ru Lin; Jih Jung Chen; Shen Fan Lin; Yang Chang Wu; Tsong Long Hwang; Lee Shing Fang

doi:10.1248/cpb.55.666

Hydroperoxysterols from the tunicate Eudistoma sp.

Ping Jyun Sung^*, Mei Ru Lin, Jih Jung Chen, Shen Fan Lin, Yang Chang Wu, Tsong Long Hwang, Lee Shing Fang

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

Two 27C hydroperoxysterols, 7β-hydroperoxycholesterol (1) and its stereoisomer 7α-hydroperoxycholesterol (2), were isolated from the lipophilic extracts of a Formosan tunicate belonging to the genus Eudistoma. The structures of sterols 1 and 2 were elucidated on the basis of extensive spectral data analyses. Cytotoxicity of sterols 1 and 2 against a limited panel of cancer cell lines is also described. Sterol 1 show weak inhibitory effects on human neutrophil elastase release.

Original language	English
Pages (from-to)	666-668
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	55
Issue number	4
DOIs	https://doi.org/10.1248/cpb.55.666
State	Published - 04 2007

Keywords

Cytotoxicity
Eudistoma
Human neutrophil elastase
Hydroperoxysterol
Tunicate

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10.1248/cpb.55.666

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title = "Hydroperoxysterols from the tunicate Eudistoma sp.",

abstract = "Two 27C hydroperoxysterols, 7β-hydroperoxycholesterol (1) and its stereoisomer 7α-hydroperoxycholesterol (2), were isolated from the lipophilic extracts of a Formosan tunicate belonging to the genus Eudistoma. The structures of sterols 1 and 2 were elucidated on the basis of extensive spectral data analyses. Cytotoxicity of sterols 1 and 2 against a limited panel of cancer cell lines is also described. Sterol 1 show weak inhibitory effects on human neutrophil elastase release.",

keywords = "Cytotoxicity, Eudistoma, Human neutrophil elastase, Hydroperoxysterol, Tunicate",

author = "Sung, {Ping Jyun} and Lin, {Mei Ru} and Chen, {Jih Jung} and Lin, {Shen Fan} and Wu, {Yang Chang} and Hwang, {Tsong Long} and Fang, {Lee Shing}",

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doi = "10.1248/cpb.55.666",

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volume = "55",

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journal = "Chemical and Pharmaceutical Bulletin",

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T1 - Hydroperoxysterols from the tunicate Eudistoma sp.

AU - Sung, Ping Jyun

AU - Lin, Mei Ru

AU - Chen, Jih Jung

AU - Lin, Shen Fan

AU - Wu, Yang Chang

AU - Hwang, Tsong Long

AU - Fang, Lee Shing

PY - 2007/4

Y1 - 2007/4

N2 - Two 27C hydroperoxysterols, 7β-hydroperoxycholesterol (1) and its stereoisomer 7α-hydroperoxycholesterol (2), were isolated from the lipophilic extracts of a Formosan tunicate belonging to the genus Eudistoma. The structures of sterols 1 and 2 were elucidated on the basis of extensive spectral data analyses. Cytotoxicity of sterols 1 and 2 against a limited panel of cancer cell lines is also described. Sterol 1 show weak inhibitory effects on human neutrophil elastase release.

AB - Two 27C hydroperoxysterols, 7β-hydroperoxycholesterol (1) and its stereoisomer 7α-hydroperoxycholesterol (2), were isolated from the lipophilic extracts of a Formosan tunicate belonging to the genus Eudistoma. The structures of sterols 1 and 2 were elucidated on the basis of extensive spectral data analyses. Cytotoxicity of sterols 1 and 2 against a limited panel of cancer cell lines is also described. Sterol 1 show weak inhibitory effects on human neutrophil elastase release.

KW - Cytotoxicity

KW - Eudistoma

KW - Human neutrophil elastase

KW - Hydroperoxysterol

KW - Tunicate

UR - http://www.scopus.com/inward/record.url?scp=34147201260&partnerID=8YFLogxK

U2 - 10.1248/cpb.55.666

DO - 10.1248/cpb.55.666

M3 - 文章

C2 - 17409569

AN - SCOPUS:34147201260

SN - 0009-2363

VL - 55

SP - 666

EP - 668

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 4

ER -

Hydroperoxysterols from the tunicate Eudistoma sp.

Abstract

Keywords

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