Hypercalcemia in prostate cancer with positive neuron-specific enolase stain

Ching Heng Wu, Yii Jenq Lan, Cheng Hsu Wang, Mai Szu Wu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations


Hypercalcemia is a common complication of malignant diseases with or without bone metastasis. Hypercalcemia in prostate cancer is rarely seen. The exact mechanism of prostate cancer-related hypercalcemia is still uncertain. Secretion of parathyroid hormone-related peptides (PTH-rP) is thought to be one of the possible mechanisms. We reported a rare case of prostate cancer with hypercalcemia (13 mg/dL). Bone marrow biopsy showed metastatic adenocarcinoma. The cells were also positive for neuron-specific enolase, which is the specific marker for neuroendocrine cell. The finding suggested that the prostate cancer cell derived from the neuroendocrine cell, which might synthesize PTH-rP and be responsible for the observed hypercalcemia.

Original languageEnglish
Pages (from-to)325-327
Number of pages3
JournalRenal Failure
Issue number3
StatePublished - 2004
Externally publishedYes


  • Hypercalcemia
  • Neuron-specific enolase
  • Parathyroid hormone-related peptide
  • Prostate cancer


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