Abstract
Homocysteine is an independent risk factor for vascular thrombosis involving the coagulation cascades and vascular wall. An increase of homocysteine is known to perturb the protein C anticoagulant system by generating activated protein C resistance or suppressing thrombomodulin. Its effect to protein C and S activity is rarely mentioned in stroke patients. In this study, we examined the relation between plasma homocysteine level and protein C or S activity in cerebral ischemia patients. There were 27.7% patients to have plasma homocysteine levels over 15 μM/L. The plasma homocysteine levels were significantly higher in hypertensive (p = 0.004) and male (p = 0.024) patients respectively. Hyperhomocysteinemia is not associated with the change of protein C or S activity. There was no correlation between plasma homocysteine levels and protein C or S activity. These findings did not change in relating to the size of infarct. Therefore, it is possible that hyperhomocysteinemia does not perturb protein C or S activity in cerebral ischemia subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 75-80 |
| Number of pages | 6 |
| Journal | Acta Neurologica Taiwanica |
| Volume | 12 |
| Issue number | 2 |
| State | Published - 06 2003 |
| Externally published | Yes |
Keywords
- Cerebral ischemia
- Homoysteine
- Protein C
- Protein S
