Hypermucoviscosity associated with Klebsiella pneumoniae-mediated invasive syndrome: A prospective cross-sectional study in Taiwan

Chen Hsiang Lee, Jien Wei Liu, Lin Hui Su, Chun Chih Chien, Chia Chin Li, Kuender D. Yang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

70 Scopus citations

Abstract

Objectives: To investigate the association between Klebsiella pneumoniae-mediated invasive syndrome and underlying diseases in patients and/or K. pneumoniae characteristics, including the rmpA, rmpA2, and magA genes, capsular polysaccharide (cps) K1 or K2 serotypes, hypermucoviscosity (HV) phenotype, and extended-spectrum β-lactamase (ESBL) production. Methods: This was a prospective cross-sectional study. Results: The invasive syndrome was detected in 19 of 91 patients (20.9%) with K. pneumoniae infections, and diabetes mellitus was the most common underlying disease (9 of 19). The presence of rmpA or rmpA2 was found in 91.4% of the 35 isolates with the HV phenotype, while in only 17.9% of the 56 isolates without HV phenotype. Multivariate logistic regression analysis showed that the HV phenotype was an independent risk factor for K. pneumoniae-mediated invasive syndrome (odds ratio (OR) 58.24, 95% confidence interval (CI) 7.23-468.87; p < 0.001) and was negatively associated with ESBL production (OR 0.042, 95% CI 0.005-0.331; p=0.003). Binary logistic regression analysis revealed that the invasive syndrome was not influenced by the presence of diabetes mellitus among patients infected with K. pneumoniae positive for the rmpA or rmpA2 gene, HV phenotype, or cps K1/K2 serotype. Conclusions: The HV phenotype of K. pneumoniae contributes to invasive syndrome and is a negative predictor for K. pneumoniae acquisition of ESBLs.

Original languageEnglish
Pages (from-to)e688-e692
JournalInternational Journal of Infectious Diseases
Volume14
Issue number8
DOIs
StatePublished - 08 2010

Keywords

  • Hypermucoviscosity
  • Invasive syndrome
  • Klebsiella pneumoniae
  • Taiwan

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