Hyperpolarized Carbon-13 Magnetic Resonance Imaging: Technical Considerations and Clinical Applications

Ying Chieh Lai, Ching Yi Hsieh, Yu Hsiang Juan, Kuan Ying Lu, Hsien Ju Lee, Shu Hang Ng, Yung Liang Wan, Gigin Lin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Hyperpolarized (HP) carbon-13 (13 C) MRI represents an innovative approach for noninvasive, real-time assessment of dynamic metabolic flux, with potential integration into routine clinical MRI. The use of [1-13C]pyruvate as a probe and its conversion to [1-13C]lactate constitute an extensively explored metabolic pathway. This review comprehensively outlines the establishment of HP13C-MRI, covering multidisciplinary team collaboration, hardware prerequisites, probe preparation, hyperpolarization techniques, imaging acquisition, and data analysis. This article discusses the clinical applications of HP13C-MRI across various anatomical domains, including the brain, heart, skeletal muscle, breast, liver, kidney, pancreas, and prostate. Each section highlights the specific applications and findings pertinent to these regions, emphasizing the potential versatility of HP13 C-MRI in diverse clinical contexts. This review serves as a comprehensive update, bridging technical aspects with clinical applications and offering insights into the ongoing advancements in HP13C-MRI.

Original languageEnglish
Pages (from-to)459-472
Number of pages14
JournalKorean Journal of Radiology
Volume25
Issue number5
DOIs
StatePublished - 05 2024

Bibliographical note

Copyright © 2024 The Korean Society of Radiology.

Keywords

  • Carbon 13
  • Hyperpolarized
  • Lactate
  • Magnetic resonance imaging
  • Pyruvate
  • Brain/diagnostic imaging
  • Humans
  • Carbon Isotopes
  • Magnetic Resonance Imaging/methods
  • Pyruvic Acid
  • Muscle, Skeletal/diagnostic imaging
  • Liver/diagnostic imaging

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