Abstract
Hyperpolarized (HP) carbon-13 (13 C) MRI represents an innovative approach for noninvasive, real-time assessment of dynamic metabolic flux, with potential integration into routine clinical MRI. The use of [1-13C]pyruvate as a probe and its conversion to [1-13C]lactate constitute an extensively explored metabolic pathway. This review comprehensively outlines the establishment of HP13C-MRI, covering multidisciplinary team collaboration, hardware prerequisites, probe preparation, hyperpolarization techniques, imaging acquisition, and data analysis. This article discusses the clinical applications of HP13C-MRI across various anatomical domains, including the brain, heart, skeletal muscle, breast, liver, kidney, pancreas, and prostate. Each section highlights the specific applications and findings pertinent to these regions, emphasizing the potential versatility of HP13 C-MRI in diverse clinical contexts. This review serves as a comprehensive update, bridging technical aspects with clinical applications and offering insights into the ongoing advancements in HP13C-MRI.
Original language | English |
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Pages (from-to) | 459-472 |
Number of pages | 14 |
Journal | Korean Journal of Radiology |
Volume | 25 |
Issue number | 5 |
DOIs | |
State | Published - 05 2024 |
Bibliographical note
Copyright © 2024 The Korean Society of Radiology.Keywords
- Carbon 13
- Hyperpolarized
- Lactate
- Magnetic resonance imaging
- Pyruvate
- Brain/diagnostic imaging
- Humans
- Carbon Isotopes
- Magnetic Resonance Imaging/methods
- Pyruvic Acid
- Muscle, Skeletal/diagnostic imaging
- Liver/diagnostic imaging